Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7301777 | 0.87 | TOP2A (0.53) | KDM4EGLAALDH1A1HSD17B10NPC1 | |
| SCHEMBL3871114 | 0.82 | ALDH1A1 (0.58) | KDM4ENR1H4ALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL5566202 | 0.82 | AGTR1 (0.50) | SIRT2KDM4EGLAALDH1A1HSD17B10 | |
| SCHEMBL8047226 | 0.81 | KMT2A (0.56) | SIRT2KDM4EGLAALDH1A1SMN1; SMN2 | |
| SCHEMBL14577687 | 0.81 | TSHR (0.53) | KDM4EGLAALDH1A1HSD17B10MAPT | |
| SCHEMBL4539617 | 0.80 | KDM4E (0.54) | SIRT2KDM4EGLAALDH1A1HSD17B10 | |
| SCHEMBL648231 | 0.80 | CNR2 (0.55) | KDM4EGLAALDH1A1HSD17B10MAPT | |
| SCHEMBL27851818 | 0.80 | KDM4E (0.53) | SIRT2KDM4EGLAALDH1A1HSD17B10 | |
| SCHEMBL7590166 | 0.79 | CNR2 (0.56) | KDM4EGLAALDH1A1HSD17B10MAPT | |
| SCHEMBL6971190 | 0.79 | ALDH1A1 (0.46) | KDM4ENR1H4ALDH1A1HSD17B10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1021411-B1 | BENZAMIDE DERIVATIVES AS THROMBIN INHIBITORS | GLAXO GROUP LTD (GB) | 2003-03-05 | — | — | EP | disclosed |
| US-6326386-B1 | ANTICOAGULANT | GLAXO GROUP LIMITED (GB) | 2001-12-04 | — | — | US | disclosed |