Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK33 | Q9BYT3 | 1/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.33 |
| ▸ | PRKACA | P17612 | 2/20 | 0.32 |
| ▸ | PLK4 | O00444 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.32 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.32 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | MARK3 | P27448 | 1/20 | 0.32 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6977452 | 1.00 | STK33 (0.38) | STK33NR3C1ROCK2ROCK1P2RX7 | |
| SCHEMBL14520577 | 1.00 | STK33 (0.38) | STK33NR3C1ROCK2ROCK1P2RX7 | |
| SCHEMBL14257013 | 0.91 | STK33 (0.40) | STK33NR3C1ROCK2ROCK1P2RX7 | |
| SCHEMBL14257024 | 0.91 | SSTR4 (0.34) | NR3C1P2RX7ADRB3 | |
| SCHEMBL14257036 | 0.91 | NR3C1 (0.33) | NR3C1P2RX7 | |
| SCHEMBL14257032 | 0.88 | SSTR4 (0.34) | NR3C1P2RX7ADRB3CA14 | |
| SCHEMBL14257043 | 0.88 | NR3C1 (0.32) | NR3C1P2RX7CA14 | |
| SCHEMBL14257011 | 0.88 | FEN1 (0.34) | NR3C1ROCK2ROCK1P2RX7PLK4 | |
| SCHEMBL24178115 | 0.85 | P2RX7 (0.45) | NR3C1P2RX7PRKACAPRKD3PRKCZ | |
| SCHEMBL14257020 | 0.85 | SSTR4 (0.39) | STK33NR3C1P2RX7NPSR1ADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0885888-B1 | ISOQUINOLINE DERIVATIVES AND DRUGS | HIDAKA HIROYOSHI DR (JP) | 2003-08-13 | — | — | EP | disclosed |
| US-6153608-A | Isoquinoline derivatives and drugs | NIPPON SHINYAKU CO., LTD. (JP) | 2000-11-28 | — | — | US | disclosed |
| EP-0885888-A1 | ISOQUINOLINE DERIVATIVES AND DRUGS | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1998-12-23 | — | — | EP | disclosed |