Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.40 |
| ▸ | THRB | P10828 | 2/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6980332 | 0.86 | EPHX2 (0.38) | TP53THRBEPHX2MAPTMEN1 | |
| SCHEMBL23003874 | 0.83 | NOTUM (0.41) | TP53THRBMAPTMEN1KMT2A | |
| SCHEMBL3892250 | 0.73 | ALDH1A1 (0.43) | MAPTMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL28601064 | 0.71 | SIRT1 (0.36) | TP53THRBTDP1MAPTMEN1 | |
| SCHEMBL12614499 | 0.71 | CASR (0.45) | TP53THRBTDP1MAPTMEN1 | |
| SCHEMBL12614257 | 0.69 | TP53 (0.43) | TP53THRBTDP1MAPTMEN1 | |
| SCHEMBL26645 | 0.68 | MEP1B (0.49) | TP53TDP1MAPTMEN1KMT2A | |
| SCHEMBL29454656 | 0.68 | MEP1B (0.49) | TP53TDP1MAPTMEN1KMT2A | |
| SCHEMBL21382123 | 0.68 | PTGS1 (0.39) | TP53MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL12614283 | 0.67 | CASR (0.42) | TP53THRBTDP1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140925-B1 | (3,4 DIHYDRO-2H-BENZO[1,4] OXAZINYL-METHYL)- 3-(1H-INDOL-3- YL)-ALKYL -AMINES | WYETH CORP (US) | 2003-04-23 | — | — | EP | disclosed |
| US-6313114-B1 | ANTIDEPRESSANTS | AMERICAN HOME PRODUCTS CORP | 2001-11-06 | — | — | US | disclosed |
| EP-1140925-A1 | (3,4 DIHYDRO-2H-BENZO[1,4] OXAZINYL-METHYL)- 3-(1H-INDOL-3- YL)-ALKYL -AMINES | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-10-10 | — | — | EP | disclosed |
| US-6221863-B1 | TREATING DEPRESSION IN A PATIENT | AMERICAN HOME PRODUCTS CORP. | 2001-04-24 | — | — | US | disclosed |
| WO-2000040581-A1 | 3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-07-13 | — | — | WO | disclosed |
| WO-2000040580-A1 | 3,4-DIHYDRO-2H-BENZO[1,4]OXAZINYL-METHYL[3-(1H-INDOL-3-YL)-ALKYL]-AMINES | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-07-13 | — | — | WO | disclosed |