Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL317481 | 0.76 | ALDH1A1 (0.56) | ALDH1A1TDP1L3MBTL1SMN1; SMN2MAPK1 | |
| SCHEMBL456636 | 0.74 | PDK1 (0.41) | ALDH1A1TDP1L3MBTL1KMT2ASMN1; SMN2 | |
| SCHEMBL429269 | 0.74 | ALDH1A1 (0.58) | ALDH1A1TDP1L3MBTL1NPC1RAB9A | |
| SCHEMBL6978074 | 0.74 | ALDH1A1 (0.55) | ALDH1A1TDP1L3MBTL1NPC1RAB9A | |
| SCHEMBL5154343 | 0.74 | ALDH1A1 (0.39) | ALDH1A1TDP1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL19301918 | 0.73 | ALDH1A1 (0.57) | ALDH1A1TDP1L3MBTL1NPC1RAB9A | |
| SCHEMBL30116204 | 0.73 | ALDH1A1 (0.57) | ALDH1A1TDP1L3MBTL1NPC1RAB9A | |
| SCHEMBL16950649 | 0.71 | MAPT (0.36) | ALDH1A1TDP1PKMMAPTLMNA | |
| SCHEMBL27540017 | 0.70 | MAPT (0.57) | ALDH1A1TDP1L3MBTL1NPC1RAB9A | |
| SCHEMBL1126722 | 0.70 | ALDH1A1 (0.62) | ALDH1A1TDP1L3MBTL1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218343-A4 | PYRIDINE CARBOXAMIDE OR SULFONAMIDE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | LION BIOSCIENCE AG (DE) | 2003-06-18 | — | — | EP | claimed |
| EP-1218343-A1 | PYRIDINE CARBOXAMIDE OR SULFONAMIDE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | LION Bioscience AG (DE) | 2002-07-03 | — | — | EP | claimed |
| WO-2001025203-A1 | PYRIDINE CARBOXAMIDE OR SULFONAMIDE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | LION BIOSCIENCE AG (DE) | 2001-04-12 | — | — | WO | claimed |