⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL578124 | 0.69 | NOS1 (0.34) | — | |
| SCHEMBL155319 | 0.68 | NOS1 (0.36) | — | |
| SCHEMBL20320680 | 0.65 | ALDH1A1 (0.37) | — | |
| SCHEMBL577762 | 0.64 | NOS1 (0.36) | — | |
| SCHEMBL1987237 | 0.64 | — | — | |
| SCHEMBL5732745 | 0.64 | TLR8 (0.36) | — | |
| SCHEMBL3322195 | 0.63 | — | — | |
| SCHEMBL2217685 | 0.63 | — | — | |
| SCHEMBL42407 | 0.61 | FBP1 (0.43) | — | |
| SCHEMBL23162739 | 0.60 | MEN1 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4262797-A1 | AMIDO-SUBSTITUTED PYRIDYL COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF HERPESVIRUSES | Merck Sharp & Dohme LLC (US) | 2023-10-25 | — | — | EP | disclosed |
| WO-2022132679-A1 | AMIDO-SUBSTITUTED PYRIDYL COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF HERPESVIRUSES | MERCK SHARP & DOHME CORP. (US) | 2022-06-23 | — | — | WO | disclosed |
| EP-0759755-B1 | Thiadiazolylalkoxyphenyl derivatives, their preparation and their use anti-picornaviral agents | SANOFI SYNTHELABO (FR) | 2003-08-13 | — | — | EP | disclosed |
| US-5821257-A | Thiadiazoles and their uses as antipicornaviral agents | SANOFI (FR) | 1998-10-13 | — | — | US | disclosed |
| US-5750527-A | VIRICIDES | SANOFI (FR) | 1998-05-12 | — | — | US | disclosed |
| US-5650419-A | Thiadiazoles and their use as antipicornaviral agents | SANOFI, S.A. | 1997-07-22 | — | — | US | disclosed |
| EP-0759755-A4 | THIADIAZOLES AND THEIR USE AS ANTIPICORNAVIRAL AGENTS | SANOFI WINTHROP INC (US) | 1997-05-07 | — | — | EP | disclosed |
| EP-0759755-A1 | Thiadiazolylalkoxyphenyl derivatives, their preparation and their use anti-picornaviral agents | SANOFI WINTHROP, INC. (US) | 1997-03-05 | — | — | EP | disclosed |
| US-5567719-A | Thiadiazoles and their use as antipicornaviral agents | STERLING WINTHROP, INC. (US) | 1996-10-22 | — | — | US | disclosed |
| WO-1995031198-A1 | THIADIAZOLES AND THEIR USE AS ANTIPICORNAVIRAL AGENTS | SANOFI WINTHROP, INC. (US) | 1995-11-23 | — | — | WO | disclosed |
| US-5453433-A | Viricides; antiseptics to decontaminate polio, rhino and coxsackie viruses | STERLING WINTHROP INC. (US) | 1995-09-26 | — | — | US | disclosed |