Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | GSK3B | P49841 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6978767 | 0.88 | KMT2A (0.34) | KMT2AHSD17B10MEN1HPGDKDM4E | |
| SCHEMBL6983419 | 0.79 | KDM4E (0.38) | KMT2AMEN1KDM4EGSK3B | |
| SCHEMBL706765 | 0.64 | NR4A1 (0.42) | KMT2AHSD17B10MEN1HPGDKDM4E | |
| SCHEMBL6981777 | 0.63 | AKR1C1 (0.41) | KMT2AMEN1 | |
| SCHEMBL6978140 | 0.60 | OPRM1 (0.49) | — | |
| SCHEMBL8749496 | 0.59 | MAPT (0.39) | KMT2AHSD17B10MEN1HPGDKDM4E | |
| SCHEMBL11608127 | 0.58 | NR4A1 (0.46) | KMT2AHSD17B10MEN1HPGDKDM4E | |
| SCHEMBL6968252 | 0.58 | MEN1 (0.42) | KMT2AHSD17B10MEN1HPGDKDM4E | |
| SCHEMBL28108213 | 0.58 | SLC6A3 (0.54) | — | |
| SCHEMBL28876346 | 0.58 | F2 (0.38) | KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1098893-B1 | CYCLIC COMPOUNDS USEFUL IN THE TREATMENT OF DYSLIPIDEMIA, ATHEROSCLEROSIS AND DIABETES, PHARMACEUTICAL COMPOSITIONS AND PREPARATION PROCESS | MERCK PATENT GMBH (DE) | 2003-03-26 | — | — | EP | disclosed |