Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.37 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.37 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CXCR5 | P32302 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6978767 | 0.89 | KMT2A (0.34) | KDM4EGSK3BMAPTMEN1KMT2A | |
| SCHEMBL706765 | 0.83 | NR4A1 (0.42) | KDM4EMAPTMEN1KMT2ANR4A1 | |
| SCHEMBL6981777 | 0.80 | AKR1C1 (0.41) | MEN1KMT2AAKR1C1CYP2C9LMNA | |
| SCHEMBL6978773 | 0.79 | KMT2A (0.34) | KDM4EGSK3BMEN1KMT2A | |
| SCHEMBL6982681 | 0.73 | THRB (0.44) | KDM4EMAPTMEN1KMT2AAKR1C1 | |
| SCHEMBL6971603 | 0.72 | CHRNA1 (0.40) | KDM4EMAPTMEN1KMT2ANPC1 | |
| SCHEMBL6982594 | 0.72 | HSD11B1 (0.39) | MEN1KMT2AAKR1C1NPC1CYP3A4 | |
| SCHEMBL6978477 | 0.72 | LMNA (0.39) | MEN1KMT2AAKR1C1NPC1CYP1A2 | |
| SCHEMBL6967893 | 0.72 | CNR1 (0.40) | MAPTKMT2AAKR1C1L3MBTL1 | |
| SCHEMBL6971207 | 0.69 | OPRM1 (0.44) | MAPTKMT2ANPC1RAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1098893-B1 | CYCLIC COMPOUNDS USEFUL IN THE TREATMENT OF DYSLIPIDEMIA, ATHEROSCLEROSIS AND DIABETES, PHARMACEUTICAL COMPOSITIONS AND PREPARATION PROCESS | MERCK PATENT GMBH (DE) | 2003-03-26 | — | — | EP | disclosed |