Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | DAO | P14920 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6967893 | 0.90 | CNR1 (0.40) | AKR1C1KMT2AMAPK1ALDH1A1L3MBTL1 | |
| SCHEMBL6978477 | 0.90 | LMNA (0.39) | AKR1C1MEN1KMT2AOPRM1LMNA | |
| SCHEMBL6982594 | 0.90 | HSD11B1 (0.39) | AKR1C1MEN1CYP2C9KMT2ASMN1; SMN2 | |
| SCHEMBL6981080 | 0.86 | THRB (0.44) | OPRM1LMNAOPRL1DAOALDH1A1 | |
| SCHEMBL6971207 | 0.86 | OPRM1 (0.44) | KMT2AOPRM1OPRL1MAPK1SMN1; SMN2 | |
| SCHEMBL6982681 | 0.84 | THRB (0.44) | AKR1C1MEN1KMT2AHTR2AHDAC4 | |
| SCHEMBL6971603 | 0.84 | CHRNA1 (0.40) | MEN1KMT2ALMNAHTTALDH1A1 | |
| SCHEMBL377756 | 0.84 | MAPK1 (0.40) | KMT2AHDAC4MAPK1ALDH1A1TSHR | |
| SCHEMBL6973280 | 0.83 | SLC6A2 (0.37) | MEN1CYP2C9KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL20592967 | 0.82 | AKR1C1 (0.45) | AKR1C1CYP2C9OPRM1LMNAOPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1098893-B1 | CYCLIC COMPOUNDS USEFUL IN THE TREATMENT OF DYSLIPIDEMIA, ATHEROSCLEROSIS AND DIABETES, PHARMACEUTICAL COMPOSITIONS AND PREPARATION PROCESS | MERCK PATENT GMBH (DE) | 2003-03-26 | — | — | EP | disclosed |