Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR2 | P25090 | 1/20 | 0.38 |
| ▸ | KLK1 | P06870 | 2/20 | 0.37 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.36 |
| ▸ | F10 | P00742 | 8/20 | 0.36 |
| ▸ | F9 | P00740 | 4/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.35 |
| ▸ | F2 | P00734 | 2/20 | 0.35 |
| ▸ | TMPRSS15 | P98073 | 1/20 | 0.35 |
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
| ▸ | HPN | P05981 | 1/20 | 0.35 |
| ▸ | F7 | P08709 | 3/20 | 0.34 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6982101 | 0.90 | F7 (0.39) | FPR2KLK1KLK5ITGB3ITGA2B | |
| SCHEMBL6982365 | 0.80 | ALDH1A1 (0.34) | — | |
| SCHEMBL6980170 | 0.80 | KLK1 (0.39) | KLK1KLK5ITGB3ITGA2BF10 | |
| SCHEMBL6976581 | 0.74 | ITGB3 (0.48) | KLK1KLK5ITGB3ITGA2BF7 | |
| SCHEMBL6982666 | 0.73 | ADORA2A (0.41) | KLK1KLK5ITGB3ITGA2BF10 | |
| SCHEMBL9262501 | 0.72 | KLK1 (0.42) | FPR2KLK1KLK5ITGB3ITGA2B | |
| SCHEMBL6985138 | 0.71 | ITGB3 (0.36) | ITGB3ITGA2BPRSS1TMPRSS15 | |
| SCHEMBL9263614 | 0.70 | KLK5 (0.40) | KLK1KLK5ITGB3ITGA2BF10 | |
| SCHEMBL6985761 | 0.70 | BRD4 (0.37) | F7 | |
| SCHEMBL6983774 | 0.69 | ADORA2A (0.40) | ITGB3ITGA2BF10PRSS1F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0630366-B1 | SUBSTITUTED HETEROCYCLIC DERIVATIVES USEFUL AS PLATELET AGGREGATION INHIBITORS | SEARLE & CO (US) | 2003-01-02 | — | — | EP | disclosed |
| EP-0539343-B1 | Substituted heterocyclic derivatives useful as platelet aggregation inhibitors | MONSANTO CO (US) | 2000-07-26 | — | — | EP | disclosed |
| US-5378727-A | ADMINISTERING TO MAMMALS | G. D. SEARLE & CO. (US) | 1995-01-03 | — | — | US | disclosed |
| US-5254573-A | Substituted heterocyclic derivatives useful as platelet aggregation inhibitors | MONSANTO COMPANY (US) | 1993-10-19 | — | — | US | disclosed |
| EP-0539343-A1 | Substituted heterocyclic derivatives useful as platelet aggregation inhibitors | MONSANTO COMPANY (US) | 1993-04-28 | — | — | EP | disclosed |