Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | DAO | P14920 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PRNP | P04156 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | LIG1 | P18858 | 1/20 | 0.36 |
| ▸ | FOLR1 | P15328 | 1/20 | 0.36 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.35 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.35 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.35 |
| ▸ | DUT | P33316 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3584022 | 0.85 | MRGPRX4 (0.45) | TP53DAOALDH1A1MRGPRX4TDP1 | |
| SCHEMBL16765952 | 0.82 | MAPT (0.39) | ALDH1A1LMNAPRNPRECQLRXFP1 | |
| SCHEMBL1246103 | 0.78 | DUT (0.35) | DUT | |
| SCHEMBL2142085 | 0.78 | DUT (0.35) | ALDH1A1HPGDDUTMAPT | |
| SCHEMBL2139606 | 0.78 | DUT (0.35) | DUT | |
| SCHEMBL16798209 | 0.77 | NR1I2 (0.32) | HPGDTSHRMAPK1ATMNPSR1 | |
| SCHEMBL22607900 | 0.76 | USP2 (0.38) | DAOALDH1A1LMNAHPGDDUT | |
| SCHEMBL29051983 | 0.76 | HDAC3 (0.46) | ALDH1A1LMNAPRNPRECQLRXFP1 | |
| SCHEMBL18260608 | 0.76 | KMT2A (0.39) | TP53ALDH1A1TDP1POLBHPGD | |
| SCHEMBL16798208 | 0.75 | ALDH1A1 (0.31) | ALDH1A1LMNAPRNPRECQLRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11667630-B2 | Nitrogen-containing 6-membered cyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2023-06-06 | — | — | US | disclosed |
| CN-111511736-B | Nitrogen-containing 6-membered ring compound | 旭化成制药株式会社 | 2023-03-24 | — | — | CN | disclosed |
| EP-3733665-B1 | 2-OXO-1,3,4-THIADIAZINAN-3-YL MOIETY CONTAINING COMPOUNDS WITH EP4 RECEPTOR AGONIST ACTIVITY | ASAHI KASEI PHARMA CORP (JP) | 2022-09-28 | — | — | EP | disclosed |
| US-20210188837-A1 | NITROGEN-CONTAINING 6-MEMBERED CYCLIC COMPOUND | ASAHI KASEI PHARMA CORPORATION (JP) | 2021-06-24 | — | — | US | disclosed |
| US-20210188837-A1 | NITROGEN-CONTAINING 6-MEMBERED CYCLIC COMPOUND | ASAHI KASEI PHARMA CORPORATION (JP) | 2021-06-24 | — | — | US | disclosed |
| US-10988468-B2 | Nitrogen-containing 6-membered cyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2021-04-27 | — | — | US | disclosed |
| US-10988468-B2 | Nitrogen-containing 6-membered cyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2021-04-27 | — | — | US | disclosed |
| US-20200347046-A1 | NITROGEN-CONTAINING 6-MEMBERED CYCLIC COMPOUND | ASAHI KASEI PHARMA CORPORATION (JP) | 2020-11-05 | — | — | US | disclosed |
| US-20200347046-A1 | NITROGEN-CONTAINING 6-MEMBERED CYCLIC COMPOUND | ASAHI KASEI PHARMA CORPORATION (JP) | 2020-11-05 | — | — | US | disclosed |
| EP-3733665-A1 | NITROGEN-CONTAINING SIX-MEMBERED RING COMPOUND | Asahi Kasei Pharma Corporation (JP) | 2020-11-04 | — | — | EP | disclosed |
| EP-1109560-B1 | COMPOUNDS USEFUL AS AICARFT INHIBITORS | AGOURON PHARMA (US) | 2003-08-27 | — | — | EP | disclosed |
| US-6525050-B1 | Inhibit the enzyme aminoimidazole carboxamide ribonucleotide formyl transferase; antiproliferative agents; antitumor, antiinflammatory, antipsoriatic, and/or immunosuppressive | AGOURON PHARMACEUTICALS, INC. | 2003-02-25 | — | — | US | disclosed |
| US-20020173515-A1 | Antiproliferative substituted 5-thiapyrimidinone and 5-selenopyrimidinone compounds | VARNEY MICHAEL D (US) | 2002-11-21 | — | — | US | disclosed |
| EP-1109560-A4 | COMPOUNDS USEFUL AS AICARFT INHIBITORS | AGOURON PHARMA (US) | 2002-04-17 | — | — | EP | disclosed |
| US-6323210-B2 | TRANSFERASE INHIBITOR | AGOURON PHARMACEUTICALS, INC. | 2001-11-27 | — | — | US | disclosed |
| US-20010018443-A1 | Antiproliferative substituted 5-thiapyrimidinone and 5-selenopyrimidinone compounds | VARNEY MICHAEL D (US) | 2001-08-30 | — | — | US | disclosed |
| EP-1109560-A1 | COMPOUNDS USEFUL AS AICARFT INHIBITORS | AGOURON PHARMACEUTICALS, INC. (US) | 2001-06-27 | — | — | EP | disclosed |
| US-6207670-B1 | USE TO INHIBIT GROWTH AND PROLIFERATION OF CELLS OF HIGHER ORGANISMS AND MICROORGANISMS SUCH AS BACTERIA, YEAST AND FUNGI | AGOURON PHARMACEUTICALS, INC. | 2001-03-27 | — | — | US | disclosed |
| WO-2000013688-A1 | COMPOUNDS USEFUL AS AICARFT INHIBITORS | AGOURON PHARMACEUTICALS, INC. (US) | 2000-03-16 | — | — | WO | disclosed |
| EP-0674516-B1 | ANTIPROLIFERATIVE SUBSTITUTED 5-THIAPYRIMIDINONE AND 5-SELENOPYRIMIDINONE COMPOUNDS | AGOURON PHARMA (US) | 2000-02-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210188837-A1 | NITROGEN-CONTAINING 6-MEMBERED CYCLIC COMPOUND | PTGER4, EPB41, BMP4 | TP53 4551/4885DAO 2561/4885ALDH1A1 3705/4885 |
| US-10988468-B2 | Nitrogen-containing 6-membered cyclic compound | PTGER4, EPB41, BMP4 | TP53 4551/4885DAO 2561/4885ALDH1A1 3705/4885 |
| US-20010018443-A1 | Antiproliferative substituted 5-thiapyrimidinone and 5-selenopyrimidinone compounds | GART, GARS1, NUDT1 | TP53 1784/4885DAO 782/4885ALDH1A1 250/4885 |
| US-11667630-B2 | Nitrogen-containing 6-membered cyclic compound | PTGER4, EPB41, BMP4 | TP53 4551/4885DAO 2561/4885ALDH1A1 3705/4885 |
| US-20200347046-A1 | NITROGEN-CONTAINING 6-MEMBERED CYCLIC COMPOUND | PTGER4, EPB41, BMP4 | TP53 4551/4885DAO 2561/4885ALDH1A1 3705/4885 |
| US-20020173515-A1 | Antiproliferative substituted 5-thiapyrimidinone and 5-selenopyrimidinone compounds | GART, GARS1, NUDT1 | TP53 1784/4885DAO 782/4885ALDH1A1 250/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.