Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BMP1 | P13497 | 5/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | IDH1 | O75874 | 1/20 | 0.32 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.32 |
| ▸ | REN | P00797 | 6/20 | 0.32 |
| ▸ | MMP3 | P08254 | 2/20 | 0.31 |
| ▸ | MMP1 | P03956 | 1/20 | 0.31 |
| ▸ | MMP13 | P45452 | 1/20 | 0.31 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6987232 | 0.94 | BMP1 (0.37) | BMP1MMP2CYP19A1IDH1GPR88 | |
| SCHEMBL6988232 | 0.90 | MMP1 (0.35) | CYP19A1IDH1GPR88RENMMP1 | |
| SCHEMBL6986904 | 0.89 | REN (0.36) | BMP1MMP2RENMMP3MMP1 | |
| SCHEMBL7930165 | 0.89 | BMP1 (0.34) | BMP1MMP2GPR88RENMMP3 | |
| SCHEMBL7142422 | 0.88 | APP (0.39) | BMP1MMP2CYP19A1IDH1GPR88 | |
| SCHEMBL6983470 | 0.86 | BMP1 (0.39) | BMP1MMP2RENMMP3MMP1 | |
| SCHEMBL6981390 | 0.83 | BMP1 (0.37) | BMP1MMP2REN | |
| SCHEMBL6988475 | 0.81 | APP (0.35) | BMP1MMP2IDH1MMP3MMP1 | |
| SCHEMBL7808351 | 0.80 | CYP19A1 (0.35) | CYP19A1IDH1GPR88RENMEN1 | |
| SCHEMBL6982041 | 0.79 | BMP1 (0.39) | BMP1MMP2RENPSMB5LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089964-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | EP | disclosed |
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |