Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BMP1 | P13497 | 7/20 | 0.37 |
| ▸ | MMP2 | P08253 | 2/20 | 0.37 |
| ▸ | IDH1 | O75874 | 1/20 | 0.33 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.32 |
| ▸ | REN | P00797 | 1/20 | 0.32 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | MC3R | P41968 | 1/20 | 0.30 |
| ▸ | APP | P05067 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6979967 | 0.94 | BMP1 (0.33) | BMP1MMP2IDH1GPR88REN | |
| SCHEMBL6988232 | 0.94 | MMP1 (0.35) | IDH1GPR88RENCYP19A1MEN1 | |
| SCHEMBL6981390 | 0.89 | BMP1 (0.37) | BMP1MMP2RENAPP | |
| SCHEMBL6982041 | 0.86 | BMP1 (0.39) | BMP1MMP2RENPSMB5 | |
| SCHEMBL6981709 | 0.85 | BMP1 (0.38) | BMP1MMP2RENPSMB5APP | |
| SCHEMBL7930165 | 0.83 | BMP1 (0.34) | BMP1MMP2GPR88RENPSMB5 | |
| SCHEMBL6986904 | 0.83 | REN (0.36) | BMP1MMP2REN | |
| SCHEMBL6980505 | 0.82 | MMP1 (0.36) | MMP2GPR88RENMEN1KMT2A | |
| SCHEMBL6981510 | 0.82 | BMP1 (0.38) | BMP1MMP2GPR88REN | |
| SCHEMBL6982289 | 0.82 | MMP1 (0.37) | RENAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089964-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | EP | disclosed |
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |