SCHEMBL6980381

SCHEMBL6980381

CC(=O)Oc1cc(F)ccc1OCC1CO1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.48
GLA P06280 1/20 0.48
VDR P11473 1/20 0.41
TSHR P16473 4/20 0.41
TP53 P04637 2/20 0.40
CYP3A4 P08684 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
HIF1A Q16665 1/20 0.40
SCN9A Q15858 1/20 0.39
KDM4E B2RXH2 2/20 0.39
GAA P10253 1/20 0.39
RAB9A P51151 1/20 0.39
CYP4F2 P78329 1/20 0.38
CYP4A11 Q02928 1/20 0.38
DRD4 P21917 1/20 0.38
RBP4 P02753 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
SSTR4 P31391 1/20 0.37
MEN1 O00255 1/20 0.36
CYP1A2 P05177 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13416124 0.85 ALDH1A1 (0.61) ALDH1A1GLATSHRTP53CYP3A4
SCHEMBL20612384 0.85 CFD (0.43) ALDH1A1GLAVDRTSHRTP53
SCHEMBL1042328 0.84 PTPN1 (0.49) ALDH1A1GLAVDRTSHRTP53
SCHEMBL568467 0.83 ALDH1A1 (0.49) ALDH1A1GLAVDRTSHRTP53
SCHEMBL567908 0.83 ALDH1A1 (0.49) ALDH1A1GLAVDRTSHRTP53
SCHEMBL24328600 0.83 FDPS (0.43) ALDH1A1GLAVDRTSHRSMN1; SMN2
SCHEMBL24328789 0.83 FDPS (0.43) ALDH1A1GLAVDRTSHRSMN1; SMN2
SCHEMBL24329411 0.83 FDPS (0.43) ALDH1A1GLAVDRTSHRSMN1; SMN2
SCHEMBL7713504 0.81 ALDH1A1 (0.51) ALDH1A1GLAVDRTSHRTP53
SCHEMBL1019652 0.80 PKM (0.41) ALDH1A1GLAVDRTSHRSCN9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0839145-B1 HETEROCYCLYLCARBOXAMIDE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS ABBOTT GMBH & CO KG (DE) 2003-11-05 EP disclosed
US-5935973-A AFFINITY FOR 5-HT1A, ALPHA1, ALPHA2 AND/OR D2 RECEPTORS; ANTIDEPRESSANTS, ANXIOLYTIC AGENTS, PSYCHOSES, DYSKINESIAS, PARKINSON'S DISEASE, HYPOTENSIVE AGENTS, TOURETTE'S SYNDROME, OBSESSIVE-COMPULSIVE BEHAVIOUR, PANIC ATTACKS, SOCIAL PHOBIAS KNOLL AKTIENGESELLSCHAFT (DE) 1999-08-10 US disclosed
EP-0839145-A1 HETEROCYCLYLCARBOXAMIDE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS Knoll AG (DE) 1998-05-06 EP disclosed
WO-1997003071-A1 HETEROCYCLYLCARBOXAMIDE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS KNOLL AKTIENGESELLSCHAFT (DE) 1997-01-30 WO disclosed