Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | PRKCB | P05771 | 4/20 | 0.40 |
| ▸ | PRKCA | P17252 | 4/20 | 0.40 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.40 |
| ▸ | PRKCH | P24723 | 1/20 | 0.40 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.40 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6974638 | 0.94 | PRKCB (0.40) | PIM1CAMK2DSIRT2PRKCBPRKCA | |
| Trifluoroacetic Acid SCHEMBL6986763 | 0.93 | TPSAB1 (0.38) | PIM1CAMK2DSIRT2PRKCBPRKCA | |
| SCHEMBL6976156 | 0.89 | CHRM1 (0.44) | SIRT2PRKCAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL6984203 | 0.89 | PIM1 (0.41) | PIM1CAMK2DPRKCACCNT1CDK9 | |
| Trifluoroacetic Acid SCHEMBL6981001 | 0.87 | TPSAB1 (0.41) | PIM1CAMK2DSIRT2PRKCBPRKCA | |
| SCHEMBL6977406 | 0.87 | CAMK2D (0.56) | PIM1CAMK2DCCNT1CDK9 | |
| SCHEMBL6983884 | 0.87 | PIM1 (0.39) | PIM1CAMK2DSIRT2PRKCBPRKCA | |
| Hydrochloric Acid SCHEMBL6978191 | 0.86 | PIM1 (0.39) | PIM1CAMK2DSIRT2PRKCBPRKCA | |
| SCHEMBL6975973 | 0.86 | CAMK2D (0.53) | PIM1CAMK2DPRKCACCNT1CDK9 | |
| SCHEMBL6983267 | 0.85 | CCNE2 (0.45) | PIM1CAMK2DCCNT1CDK9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1095039-B1 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRAZENECA AB (SE) | 2003-08-27 | — | — | EP | claimed |
| US-6346625-B1 | ENZYME INHIBITORS FOR PROTEIN KINASES | ASTRAZENECA AB (SE) | 2002-02-12 | — | — | US | claimed |
| EP-1095039-A2 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | AstraZeneca AB (SE) | 2001-05-02 | — | — | EP | claimed |
| WO-2000002877-A2 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRAZENECA AB (SE) | 2000-01-20 | — | — | WO | claimed |
| EP-1095039-B1 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRAZENECA AB (SE) | 2003-08-27 | — | — | EP | disclosed |
| US-6346625-B1 | ENZYME INHIBITORS FOR PROTEIN KINASES | ASTRAZENECA AB (SE) | 2002-02-12 | — | — | US | disclosed |