Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPSAB1 | Q15661 | 10/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | PRKCB | P05771 | 2/20 | 0.36 |
| ▸ | PRKCA | P17252 | 2/20 | 0.36 |
| ▸ | PRKCH | P24723 | 1/20 | 0.36 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.36 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.36 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL6986763 | 0.95 | TPSAB1 (0.38) | TPSAB1SIRT2PRKCBPRKCAPRKCH | |
| SCHEMBL6974638 | 0.93 | PRKCB (0.40) | SIRT2PRKCBPRKCAPRKCHPRKCE | |
| Trifluoroacetic Acid SCHEMBL6978586 | 0.90 | F10 (0.40) | SIRT2PRKCBPRKCAPRKCHPRKCE | |
| Trifluoroacetic Acid SCHEMBL6985520 | 0.89 | PIM1 (0.36) | TPSAB1PIM1CAMK2D | |
| Trifluoroacetic Acid SCHEMBL6984982 | 0.87 | TPSAB1 (0.40) | TPSAB1CAMK2DCA12CA1CA2 | |
| SCHEMBL6980594 | 0.87 | PIM1 (0.41) | SIRT2PRKCBPRKCAPRKCHPRKCE | |
| Trifluoroacetic Acid SCHEMBL6977475 | 0.87 | CAMK2D (0.48) | PIM1CAMK2D | |
| Trifluoroacetic Acid SCHEMBL6982808 | 0.86 | CAMK2D (0.46) | SIRT2PRKCBPRKCAPRKCHPRKCE | |
| Trifluoroacetic Acid SCHEMBL6977279 | 0.83 | CAMK2D (0.41) | SIRT2PRKCBPRKCAPRKCHPRKCE | |
| SCHEMBL7674311 | 0.83 | F10 (0.42) | SIRT2PRKCBPRKCAPRKCHPRKCE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1095039-B1 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRAZENECA AB (SE) | 2003-08-27 | — | — | EP | disclosed |
| US-6346625-B1 | ENZYME INHIBITORS FOR PROTEIN KINASES | ASTRAZENECA AB (SE) | 2002-02-12 | — | — | US | disclosed |