Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | NNMT | P40261 | 1/20 | 0.36 |
| ▸ | CACNA1I | Q9P0X4 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6983249 | 0.92 | KMT2A (0.44) | POLBALDH1A1HTTMAPK1NPC1 | |
| SCHEMBL6988211 | 0.90 | POLB (0.40) | POLBALDH1A1HTTMAPK1NPC1 | |
| SCHEMBL6985151 | 0.88 | KMT2A (0.55) | POLBALDH1A1HTTMAPK1NPC1 | |
| SCHEMBL6991687 | 0.87 | KMT2A (0.42) | POLBALDH1A1HTTMAPK1NPC1 | |
| SCHEMBL6990458 | 0.82 | CSF1R (0.44) | ALDH1A1NPC1RAB9AKMT2ALMNA | |
| SCHEMBL6989465 | 0.82 | NPC1 (0.41) | POLBHTTNPC1RAB9AKMT2A | |
| SCHEMBL6990394 | 0.79 | NPC1 (0.40) | ALDH1A1NPC1RAB9AKMT2AKDM4E | |
| SCHEMBL6991619 | 0.77 | TYK2 (0.37) | MAPT | |
| SCHEMBL4256402 | 0.77 | POLB (0.42) | POLBALDH1A1HTTMAPK1NPC1 | |
| SCHEMBL4256399 | 0.77 | POLB (0.42) | POLBALDH1A1HTTMAPK1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358160-A1 | AMINAL DIONES AS POTASSIUM CHANNEL OPENERS | Abbott Laboratories (US) | 2003-11-05 | — | — | EP | claimed |
| WO-2002062761-A1 | AMINAL DIONES AS POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2002-08-15 | — | — | WO | claimed |