Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.38 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6988211 | 0.82 | POLB (0.40) | NPC1RAB9AL3MBTL1MEN1KMT2A | |
| SCHEMBL6981005 | 0.82 | POLB (0.42) | NPC1RAB9AL3MBTL1GAAMEN1 | |
| SCHEMBL6981925 | 0.80 | NAMPT (0.50) | NPC1RAB9AMEN1KMT2ACYP1A2 | |
| SCHEMBL6991687 | 0.80 | KMT2A (0.42) | NPC1RAB9AMEN1KMT2ACYP1A2 | |
| SCHEMBL6983249 | 0.80 | KMT2A (0.44) | NPC1RAB9AL3MBTL1MEN1KMT2A | |
| SCHEMBL6990741 | 0.79 | GABRA5 (0.35) | NPC1RAB9AMEN1KMT2ACYP1A2 | |
| SCHEMBL6990809 | 0.78 | MEN1 (0.48) | NPC1RAB9AGAAMEN1KMT2A | |
| SCHEMBL6989221 | 0.78 | KCNJ11 (0.45) | NPC1RAB9AL3MBTL1GAAKDR | |
| SCHEMBL6985151 | 0.77 | KMT2A (0.55) | NPC1RAB9AL3MBTL1MEN1KMT2A | |
| SCHEMBL6991619 | 0.77 | TYK2 (0.37) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358160-A1 | AMINAL DIONES AS POTASSIUM CHANNEL OPENERS | Abbott Laboratories (US) | 2003-11-05 | — | — | EP | claimed |
| WO-2002062761-A1 | AMINAL DIONES AS POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2002-08-15 | — | — | WO | claimed |