Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6981005 | 0.92 | POLB (0.42) | KMT2AMEN1L3MBTL1POLBKCNH2 | |
| SCHEMBL6985151 | 0.92 | KMT2A (0.55) | KMT2AMEN1L3MBTL1POLBRAB9A | |
| SCHEMBL6991687 | 0.91 | KMT2A (0.42) | KMT2AMEN1POLBRAB9ANPC1 | |
| SCHEMBL6988211 | 0.87 | POLB (0.40) | KMT2AMEN1L3MBTL1POLBRAB9A | |
| SCHEMBL6986333 | 0.83 | MEN1 (0.48) | KMT2AMEN1POLBKCNH2CACNA1I | |
| SCHEMBL6990616 | 0.82 | KMT2A (0.50) | KMT2AMEN1POLBGRM5RAB9A | |
| SCHEMBL4367794 | 0.81 | GRM5 (0.45) | KMT2AMEN1KCNH2CACNA1IGRM5 | |
| SCHEMBL6989465 | 0.80 | NPC1 (0.41) | KMT2AMEN1L3MBTL1POLBRAB9A | |
| SCHEMBL6983246 | 0.78 | KMT2A (0.44) | KMT2AMEN1L3MBTL1POLBGRM5 | |
| SCHEMBL6990394 | 0.77 | NPC1 (0.40) | KMT2AMEN1RAB9ANPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358160-A1 | AMINAL DIONES AS POTASSIUM CHANNEL OPENERS | Abbott Laboratories (US) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002062761-A1 | AMINAL DIONES AS POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2002-08-15 | — | — | WO | disclosed |