Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5845218 | 0.99 | MEN1 (0.46) | KCNH2MEN1GAAKMT2AALDH1A1 | |
| SCHEMBL6986873 | 0.85 | SHMT2 (0.44) | KCNH2 | |
| Hydrochloric Acid SCHEMBL5840949 | 0.84 | SHMT2 (0.44) | KCNH2 | |
| SCHEMBL6985106 | 0.82 | SIGMAR1 (0.43) | KCNH2 | |
| SCHEMBL5841208 | 0.82 | SHMT2 (0.44) | KCNH2 | |
| Hydrochloric Acid SCHEMBL5840340 | 0.81 | SHMT2 (0.43) | — | |
| SCHEMBL6986781 | 0.81 | SHMT2 (0.43) | KCNH2 | |
| Hydrochloric Acid SCHEMBL5841820 | 0.81 | SIGMAR1 (0.43) | KCNH2MEN1KMT2APOLB | |
| SCHEMBL6984898 | 0.81 | SLC29A1 (0.69) | KCNH2MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL5842747 | 0.80 | SHMT2 (0.42) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1275647-B1 | Octahydro-2H-pyrido[1,2-a]pyrazine derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-11-12 | — | — | EP | disclosed |
| EP-1275647-A1 | Octahydro-2H-pyrido[1,2-a]pyrazine derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2003-01-15 | — | — | EP | disclosed |