Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.69 |
| ▸ | ATM | Q13315 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5842825 | 0.99 | SLC29A1 (0.67) | SLC29A1ATMSMN1; SMN2HSD17B10MEN1 | |
| SCHEMBL6986873 | 0.83 | SHMT2 (0.44) | SLC29A1KCNH2 | |
| SCHEMBL9199428 | 0.82 | SLC29A1 (1.00) | SLC29A1ATMSMN1; SMN2HSD17B10MEN1 | |
| Hydrochloric Acid SCHEMBL5840949 | 0.82 | SHMT2 (0.44) | SLC29A1SMN1; SMN2KCNH2 | |
| SCHEMBL6981147 | 0.81 | KCNH2 (0.47) | MEN1KMT2AKCNH2 | |
| SCHEMBL6986043 | 0.80 | SHMT2 (0.50) | SLC29A1ATMSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL5845218 | 0.80 | MEN1 (0.46) | MEN1KMT2AKCNH2 | |
| SCHEMBL5841208 | 0.80 | SHMT2 (0.44) | SLC29A1KCNH2 | |
| Hydrochloric Acid SCHEMBL5843596 | 0.80 | SHMT2 (0.49) | ATMSMN1; SMN2MAPT | |
| SCHEMBL9129159 | 0.79 | SLC29A1 (0.89) | SLC29A1ATMSMN1; SMN2HSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1275647-B1 | Octahydro-2H-pyrido[1,2-a]pyrazine derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-11-12 | — | — | EP | disclosed |
| EP-1275647-A1 | Octahydro-2H-pyrido[1,2-a]pyrazine derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2003-01-15 | — | — | EP | disclosed |