SCHEMBL6981368

SCHEMBL6981368

Cc1cn2c3ccc(Br)cc3c3cc(O)cc(c1=O)c32

nearest known ligand 0.38

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.38
ABCC2 Q92887 3/20 0.38
MAPK8 P45983 1/20 0.37
HTT P42858 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35
CYP1A2 P05177 1/20 0.34
SMN1; SMN2 Q16637 3/20 0.34
CNR2 P34972 2/20 0.34
ALDH1A1 P00352 1/20 0.34
MAPT P10636 2/20 0.33
DNM1 Q05193 3/20 0.33
ESR2 Q92731 1/20 0.33
CA12 O43570 1/20 0.33
CA9 Q16790 1/20 0.33
CNR1 P21554 1/20 0.32
GSK3B P49841 1/20 0.32
TSPO P30536 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6972004 0.89 EGLN1 (0.34) LMNAABCC2MAPK8ALDH1A1MAPT
SCHEMBL6975262 0.84 PIK3R1 (0.38) LMNAMAPK8NPSR1SMN1; SMN2ALDH1A1
SCHEMBL6979851 0.82 LMNA (0.41) LMNAMAPK8HTTSMN1; SMN2CNR2
SCHEMBL6975925 0.80 PTGDR2 (0.41) LMNAALDH1A1
SCHEMBL6984498 0.79 LMNA (0.36) LMNACNR2MAPTCNR1
SCHEMBL6978232 0.77 CHEK1 (0.36) LMNAABCC2HTTNPSR1CYP1A2
SCHEMBL6976583 0.77 LMNA (0.40) LMNAHTTNPSR1SMN1; SMN2CNR2
SCHEMBL6983087 0.77 LMNA (0.44) LMNANPSR1SMN1; SMN2ALDH1A1MAPT
SCHEMBL6984474 0.75 TNFRSF1A (0.36) LMNAHTTNPSR1ALDH1A1MAPT
SCHEMBL6978066 0.74 GABRA1 (0.40) LMNAHTTNPSR1CYP1A2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0985671-B1 PYRIDOCARBAZOLE DERIVATIVES HAVING cGMP-PDE INHIBITORY EFFECT MOCHIDA PHARM CO LTD (JP) 2003-04-02 EP disclosed
US-6197768-B1 THERAPY, PREVENTION ISCHEMIC HEART DISEASE MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 2001-03-06 US disclosed
EP-0992240-A1 THERAPEUTIC AGENT FOR ERECTION FAILURE MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 2000-04-12 EP disclosed
EP-0985671-A1 PYRIDOCARBAZOLE DERIVATIVES HAVING cGMP-PDE INHIBITORY EFFECT MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 2000-03-15 EP disclosed
US-6018046-A SELECTIVE ACTION IN INHIBITING CYCLIC GMP-PHOSPHODIESTERASE (CGMP-PDE); PHARMACEUTICALS FOR TREATING DISEASES AGAINST WHICH THE INHIBITORY ACTION IS EFFECTIVE, SUCH AS PULMONARY HYPERTENSION MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 2000-01-25 US disclosed