SCHEMBL6976583

SCHEMBL6976583

CCCC(=O)COc1cc2c(=O)c(C)cn3c4ccc(Br)cc4c(c1)c23

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.40
ALDH1A1 P00352 2/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
CNR2 P34972 5/20 0.36
CNR1 P21554 4/20 0.34
IDO1 P14902 2/20 0.33
BRD4 O60885 1/20 0.33
TP53 P04637 1/20 0.33
MAPT P10636 1/20 0.33
THRB P10828 1/20 0.33
PPARG P37231 1/20 0.33
PPARA Q07869 1/20 0.33
HTT P42858 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
GABRA1 P14867 1/20 0.32
GABRB1 P18505 1/20 0.32
GABRA3 P34903 1/20 0.32
GABRB2 P47870 1/20 0.32
TSPO P30536 1/20 0.32
MCL1 Q07820 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6975925 0.89 PTGDR2 (0.41) LMNAALDH1A1THRBMCL1
SCHEMBL6983087 0.88 LMNA (0.44) LMNAALDH1A1SMN1; SMN2MAPTNPSR1
SCHEMBL6984474 0.86 TNFRSF1A (0.36) LMNAALDH1A1IDO1BRD4TP53
SCHEMBL6979976 0.84 SMN1; SMN2 (0.34) LMNAALDH1A1SMN1; SMN2CNR2IDO1
SCHEMBL6984498 0.81 LMNA (0.36) LMNACNR2CNR1IDO1BRD4
SCHEMBL6975197 0.81 ALDH1A1 (0.36) ALDH1A1CNR2CNR1MAPTHTT
SCHEMBL6979851 0.80 LMNA (0.41) LMNAALDH1A1SMN1; SMN2CNR2CNR1
SCHEMBL6975262 0.80 PIK3R1 (0.38) LMNAALDH1A1SMN1; SMN2IDO1MAPT
SCHEMBL6981368 0.77 LMNA (0.38) LMNAALDH1A1SMN1; SMN2CNR2CNR1
SCHEMBL6978066 0.74 GABRA1 (0.40) LMNAALDH1A1BRD4MAPTHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0985671-B1 PYRIDOCARBAZOLE DERIVATIVES HAVING cGMP-PDE INHIBITORY EFFECT MOCHIDA PHARM CO LTD (JP) 2003-04-02 EP disclosed
US-6197768-B1 THERAPY, PREVENTION ISCHEMIC HEART DISEASE MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 2001-03-06 US disclosed
EP-0992240-A1 THERAPEUTIC AGENT FOR ERECTION FAILURE MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 2000-04-12 EP disclosed
EP-0985671-A1 PYRIDOCARBAZOLE DERIVATIVES HAVING cGMP-PDE INHIBITORY EFFECT MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 2000-03-15 EP disclosed
US-6018046-A SELECTIVE ACTION IN INHIBITING CYCLIC GMP-PHOSPHODIESTERASE (CGMP-PDE); PHARMACEUTICALS FOR TREATING DISEASES AGAINST WHICH THE INHIBITORY ACTION IS EFFECTIVE, SUCH AS PULMONARY HYPERTENSION MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 2000-01-25 US disclosed