SCHEMBL6981893

SCHEMBL6981893

N#Cc1cc(F)c(Cl)cc1OCCC(N)c1cccnc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOS2 P35228 4/20 0.52
CYP2D6 P10635 3/20 0.52
SLC6A2 P23975 3/20 0.52
SLC6A4 P31645 3/20 0.52
EGFR P00533 5/20 0.38
MRGPRX4 Q96LA9 1/20 0.38
MAP3K8 P41279 2/20 0.37
MAPK13 O15264 1/20 0.36
EIF2AK2 P19525 1/20 0.36
MAPK12 P53778 1/20 0.36
MAPK11 Q15759 1/20 0.36
MAPK14 Q16539 1/20 0.36
ALDH1A1 P00352 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
S1PR1 P21453 1/20 0.36
S1PR3 Q99500 1/20 0.36
SLC22A12 Q96S37 1/20 0.36
CYP19A1 P11511 1/20 0.36
CYP11B1 P15538 1/20 0.35
CYP11B2 P19099 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7599969 0.86 CYP2D6 (0.46) NOS2CYP2D6SLC6A2SLC6A4EGFR
SCHEMBL6500286 0.81 NOS2 (0.76) NOS2CYP2D6SLC6A2SLC6A4EGFR
SCHEMBL6748032 0.77 NOS2 (0.55) NOS2CYP2D6SLC6A2SLC6A4EGFR
Hydrochloric Acid SCHEMBL6855357 0.76 NOS2 (0.54) NOS2CYP2D6SLC6A2SLC6A4EGFR
Hydrochloric Acid SCHEMBL6855347 0.76 NOS2 (0.54) NOS2CYP2D6SLC6A2SLC6A4EGFR
Oxalic Acid SCHEMBL6502777 0.76 NOS2 (0.80) NOS2CYP2D6SLC6A2SLC6A4MRGPRX4
SCHEMBL6489564 0.76 SLC6A4 (0.59) NOS2CYP2D6SLC6A2SLC6A4KCNH2
SCHEMBL6983849 0.74 CYP2D6 (0.44) NOS2CYP2D6SLC6A2SLC6A4EGFR
SCHEMBL6980102 0.72 CYP2D6 (0.43) NOS2CYP2D6SLC6A2SLC6A4MRGPRX4
SCHEMBL7751616 0.71 CYP11B1 (0.42) CYP19A1CYP11B1CYP11B2KCNA5KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2003523988-A 2003-08-12 JP claimed
EP-1263711-A1 NOVEL USE OF PHENYLHETEROALKYLAMINE DERIVATIVES AstraZeneca AB (SE) 2002-12-11 EP claimed
WO-2001062704-A1 NOVEL USE OF PHENYLHETEROALKYLAMINE DERIVATIVES ASTRAZENECA AB (SE) 2001-08-30 WO claimed
EP-1263711-A1 NOVEL USE OF PHENYLHETEROALKYLAMINE DERIVATIVES AstraZeneca AB (SE) 2002-12-11 EP disclosed
WO-2001062704-A1 NOVEL USE OF PHENYLHETEROALKYLAMINE DERIVATIVES ASTRAZENECA AB (SE) 2001-08-30 WO disclosed