Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 6/20 | 0.50 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.50 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.50 |
| ▸ | ABCC9 | O60706 | 4/20 | 0.46 |
| ▸ | ABCC8 | Q09428 | 4/20 | 0.46 |
| ▸ | KCNJ11 | Q14654 | 4/20 | 0.46 |
| ▸ | KCNJ8 | Q15842 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6990458 | 0.91 | CSF1R (0.44) | NAMPTCYP11B1CYP11B2KMT2AMEN1 | |
| SCHEMBL6988180 | 0.91 | NAMPT (0.51) | NAMPTKMT2ASMN1; SMN2LMNAMAPT | |
| SCHEMBL6986333 | 0.89 | MEN1 (0.48) | ABCC9ABCC8KCNJ11KCNJ8KMT2A | |
| SCHEMBL6985933 | 0.89 | CYP11B1 (0.51) | NAMPTCYP11B1CYP11B2ABCC9ABCC8 | |
| SCHEMBL6990861 | 0.85 | CYP11B1 (0.56) | NAMPTCYP11B1CYP11B2ABCC9ABCC8 | |
| SCHEMBL6988688 | 0.85 | ABCC9 (0.41) | NAMPTCYP11B1CYP11B2ABCC9ABCC8 | |
| SCHEMBL7163637 | 0.85 | NAMPT (0.46) | NAMPTCYP11B1CYP11B2ABCC9ABCC8 | |
| SCHEMBL6987131 | 0.83 | GRM5 (0.44) | KMT2ASMN1; SMN2MEN1LMNAMAPT | |
| SCHEMBL6988714 | 0.83 | SIRT2 (0.43) | KMT2AMEN1RAB9A | |
| SCHEMBL6989487 | 0.83 | ALDH1A1 (0.49) | KMT2ASMN1; SMN2MEN1LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358160-A1 | AMINAL DIONES AS POTASSIUM CHANNEL OPENERS | Abbott Laboratories (US) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002062761-A1 | AMINAL DIONES AS POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2002-08-15 | — | — | WO | disclosed |