Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.42 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | IDE | P14735 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6986333 | 0.89 | MEN1 (0.48) | GRM5CSF1RTBXA2RTBXAS1NPC1 | |
| SCHEMBL6988714 | 0.89 | SIRT2 (0.43) | TBXA2RTBXAS1L3MBTL1KMT2AMEN1 | |
| SCHEMBL6988050 | 0.88 | ALPL (0.43) | TBXA2RTBXAS1L3MBTL1MAPK1KMT2A | |
| SCHEMBL6988688 | 0.85 | ABCC9 (0.41) | TBXA2RTBXAS1L3MBTL1NPC1TSHR | |
| SCHEMBL6990458 | 0.85 | CSF1R (0.44) | CSF1RTBXA2RTBXAS1NPC1KMT2A | |
| SCHEMBL6988180 | 0.84 | NAMPT (0.51) | NPC1KMT2ALMNAMAPTSMN1; SMN2 | |
| SCHEMBL6981925 | 0.83 | NAMPT (0.50) | MAPK1NPC1KMT2AMEN1TSHR | |
| SCHEMBL6989487 | 0.83 | ALDH1A1 (0.49) | KMT2AMEN1TSHRLMNASMN1; SMN2 | |
| SCHEMBL4367794 | 0.79 | GRM5 (0.45) | GRM5NPC1KMT2AMEN1CYP1A2 | |
| SCHEMBL6987126 | 0.78 | CYP1A2 (0.46) | GRM5CSF1RTBXA2RTBXAS1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358160-A1 | AMINAL DIONES AS POTASSIUM CHANNEL OPENERS | Abbott Laboratories (US) | 2003-11-05 | — | — | EP | claimed |
| WO-2002062761-A1 | AMINAL DIONES AS POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2002-08-15 | — | — | WO | claimed |