Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.43 |
| ▸ | CDK4 | P11802 | 1/20 | 0.42 |
| ▸ | CCND1 | P24385 | 1/20 | 0.42 |
| ▸ | KMO | O15229 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.42 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 2/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.40 |
| ▸ | BCR | P11274 | 1/20 | 0.40 |
| ▸ | BLK | P51451 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6986333 | 0.89 | MEN1 (0.48) | TBXA2RTBXAS1MEN1RAB9AKMT2A | |
| SCHEMBL6987131 | 0.89 | GRM5 (0.44) | TBXA2RTBXAS1MEN1KMT2AALDH1A1 | |
| SCHEMBL6988050 | 0.88 | ALPL (0.43) | TBXA2RTBXAS1MEN1RAB9AKMT2A | |
| SCHEMBL6990458 | 0.85 | CSF1R (0.44) | TBXA2RTBXAS1MEN1RAB9AKMT2A | |
| SCHEMBL6988688 | 0.85 | ABCC9 (0.41) | TBXA2RTBXAS1RAB9AL3MBTL1MAPKAPK2 | |
| SCHEMBL6988180 | 0.84 | NAMPT (0.51) | RAB9AKMT2AALDH1A1POLB | |
| SCHEMBL6981925 | 0.83 | NAMPT (0.50) | MEN1RAB9AKMT2A | |
| SCHEMBL6989487 | 0.83 | ALDH1A1 (0.49) | MEN1RAB9AKMT2AALDH1A1POLB | |
| SCHEMBL4367794 | 0.79 | GRM5 (0.45) | MEN1RAB9AKMT2A | |
| SCHEMBL6988709 | 0.78 | CYP1A2 (0.46) | SIRT2KMOEGFRTBXA2RTBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358160-A1 | AMINAL DIONES AS POTASSIUM CHANNEL OPENERS | Abbott Laboratories (US) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002062761-A1 | AMINAL DIONES AS POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2002-08-15 | — | — | WO | disclosed |