Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 2/20 | 0.44 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 7/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6403012 | 1.00 | FAAH (0.44) | FAAHTRPM8PDE10APDGFRBPDGFRA | |
| SCHEMBL6399537 | 0.87 | MEN1 (0.46) | FAAHPDGFRBPDGFRAMEN1KMT2A | |
| SCHEMBL6983641 | 0.87 | MEN1 (0.46) | FAAHPDGFRBPDGFRAMEN1KMT2A | |
| SCHEMBL6400650 | 0.81 | ADORA2A (0.35) | PDGFRBPDGFRAMEN1KMT2ATSHR | |
| SCHEMBL6400354 | 0.80 | ABCB11 (0.34) | PDGFRBPDGFRAMEN1KMT2ATSHR | |
| SCHEMBL6405056 | 0.80 | FAAH (0.44) | FAAHTRPM8PDE10APDGFRBPDGFRA | |
| SCHEMBL23138232 | 0.68 | CYP1A2 (0.52) | PDE10APDGFRBPDGFRARAB9AALDH1A1 | |
| SCHEMBL6405033 | 0.68 | MASP2 (0.36) | MEN1KMT2ANPC1ALDH1A1 | |
| SCHEMBL10673413 | 0.68 | CYP1A2 (0.50) | PDE10APDGFRBPDGFRARAB9AALDH1A1 | |
| SCHEMBL30542307 | 0.67 | PDGFRB (0.60) | PDGFRBPDGFRAIGF1RNPC1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1289980-A1 | BICYCLYL OR HETEROBICYCLYLMETHANESULFONYLAMINO-SUBSTITUTED N-HYDROXYFORMAMIDES | SMITHKLINE BEECHAM PLC (GB) | 2003-03-12 | — | — | EP | disclosed |
| WO-2001090100-A1 | BICYCLYL OR HETEROBICYCLYLMETHANESULFONYLAMINO-SUBSTITUTED N-HYDROXYFORMAMIDES | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-11-29 | — | — | WO | disclosed |