SCHEMBL6982065

SCHEMBL6982065

O=Cc1ccc(C(=O)C(O)O)cc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.58
ALDH5A1 P51649 1/20 0.46
ABAT P80404 1/20 0.46
PARP10 Q53GL7 1/20 0.46
PARP3 Q9Y6F1 1/20 0.46
KDM4E B2RXH2 2/20 0.41
TYR P14679 1/20 0.41
CYP2A6 P11509 4/20 0.41
HSD17B10 Q99714 1/20 0.41
ADRB2 P07550 1/20 0.41
ADRB1 P08588 1/20 0.41
ADRB3 P13945 1/20 0.41
EGFR P00533 2/20 0.38
ALDH1A3 P47895 1/20 0.38
KMT2A Q03164 1/20 0.37
PTGS2 P35354 1/20 0.37
RAB9A P51151 1/20 0.37
CYP2A13 Q16696 1/20 0.37
EPHX2 P34913 1/20 0.37
NR1H4 Q96RI1 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23419503 0.82 ALDH1A1 (0.50) ALDH1A1ALDH5A1ABATKMT2A
SCHEMBL7402179 0.80 ALDH1A1 (0.56) ALDH1A1ALDH5A1ABATPARP10PARP3
SCHEMBL20559900 0.78 ALDH1A1 (0.48) ALDH1A1ALDH5A1ABATPARP10PARP3
SCHEMBL30306602 0.77 ALDH1A1 (0.44) ALDH1A1KMT2APTGS2
SCHEMBL4461196 0.77 ALDH1A1 (0.52) ALDH1A1ALDH5A1ABATPARP10PARP3
SCHEMBL3757660 0.75 ALDH1A1 (0.68) ALDH1A1ALDH5A1ABATPARP10PARP3
SCHEMBL6852409 0.75 ALDH1A1 (0.68) ALDH1A1ALDH5A1ABATPARP10PARP3
Terephthalic Acid SCHEMBL11068404 0.73 ALDH1A1 (1.00) ALDH1A1ALDH5A1ABATPARP10PARP3
SCHEMBL18133156 0.73 ALDH1A1 (0.65) ALDH1A1ALDH5A1ABATPARP10PARP3
SCHEMBL63361 0.73 ALDH1A1 (1.00) ALDH1A1ALDH5A1ABATPARP10PARP3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1289990-A1 TETRACYCLIC DIKETOPIERAZINE COMPOUNDS AS PDEV INHIBITORS Lilly Icos LLC (US) 2003-03-12 EP disclosed
WO-2001094347-A1 TETRACYCLIC DIKETOPIPERAZINE COMPOUNDS AS PDEV INHIBITORS LILLY ICOS LLC (US) 2001-12-13 WO disclosed