Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 4/20 | 0.47 |
| ▸ | MMP13 | P45452 | 1/20 | 0.47 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | FCER2 | P06734 | 4/20 | 0.39 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MMP3 | P08254 | 3/20 | 0.37 |
| ▸ | MMP9 | P14780 | 2/20 | 0.37 |
| ▸ | MMP2 | P08253 | 2/20 | 0.36 |
| ▸ | MMP7 | P09237 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | ANPEP | P15144 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6985193 | 0.89 | MMP1 (0.50) | MMP1MMP13MMP8FCER2ADAM17 | |
| SCHEMBL6981814 | 0.82 | MMP1 (0.42) | MMP1MMP13MMP8APP | |
| SCHEMBL6980311 | 0.81 | MMP1 (0.42) | MMP1MMP13MMP8FCER2ADAM17 | |
| SCHEMBL6983240 | 0.81 | MMP1 (0.42) | MMP1MMP13MMP8FCER2ADAM17 | |
| SCHEMBL6981697 | 0.81 | MMP1 (0.43) | MMP1MMP13MMP8FCER2ADAM17 | |
| SCHEMBL6982654 | 0.79 | MMP1 (0.52) | MMP1MMP13MMP8FCER2ADAM17 | |
| SCHEMBL7099919 | 0.77 | ADAM17 (0.51) | MMP1MMP13MMP8FCER2ADAM17 | |
| SCHEMBL6988470 | 0.76 | ADAM17 (0.64) | MMP1MMP13MMP8FCER2ADAM17 | |
| SCHEMBL6982700 | 0.75 | MMP1 (0.42) | MMP1MMP13MMP8APP | |
| SCHEMBL6979941 | 0.74 | MMP1 (0.42) | MMP1MMP13MMP8FCER2ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089964-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | EP | disclosed |
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |