Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | MMP8 | P22894 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6982700 | 0.94 | MMP1 (0.42) | MMP1MMP13MMP8CYP3A4CYP2D6 | |
| SCHEMBL7816201 | 0.90 | MMP1 (0.44) | MMP1MMP13MMP8CYP3A4CYP2D6 | |
| SCHEMBL6980311 | 0.87 | MMP1 (0.42) | MMP1MMP13MMP8APP | |
| SCHEMBL6983240 | 0.87 | MMP1 (0.42) | MMP1MMP13MMP8APP | |
| SCHEMBL6980734 | 0.82 | KCNA5 (0.43) | MMP1MMP13MMP8 | |
| SCHEMBL6982089 | 0.82 | MMP1 (0.47) | MMP1MMP13MMP8APP | |
| SCHEMBL6982840 | 0.80 | MMP1 (0.42) | MMP1MMP13MMP8APP | |
| SCHEMBL6979941 | 0.80 | MMP1 (0.42) | MMP1MMP13MMP8APP | |
| SCHEMBL6988045 | 0.79 | CYP26A1 (0.38) | CYP3A4CYP2D6 | |
| SCHEMBL6984386 | 0.79 | ADAM17 (0.44) | MMP1MMP13MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089964-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | EP | disclosed |
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |
| EP-1089964-A1 | HYDRAZINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2001-04-11 | — | — | EP | disclosed |
| WO-2000000465-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-01-06 | — | — | WO | disclosed |