SCHEMBL6982117

SCHEMBL6982117

[CH](Cc1ccccc1)C(Nc1ccccc1)c1ccccc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 1/20 0.41
MAOB P27338 1/20 0.40
CYP3A4 P08684 2/20 0.38
CYP1A2 P05177 1/20 0.38
CYP2D6 P10635 1/20 0.38
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38
TDP1 Q9NUW8 2/20 0.38
SGMS2 Q8NHU3 1/20 0.35
TACR1 P25103 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.34
KDM4E B2RXH2 1/20 0.34
LMNA P02545 2/20 0.33
RECQL P46063 2/20 0.33
NPSR1 Q6W5P4 2/20 0.33
L3MBTL1 Q9Y468 2/20 0.33
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
ALDH1A1 P00352 1/20 0.33
THRB P10828 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8710872 0.76 MAOB (0.50) MAPK1MAOBSMN1; SMN2SIGMAR1KCNH2
SCHEMBL16056158 0.72 ALDH1A1 (0.43) CYP3A4CYP2D6TDP1KDM4ELMNA
SCHEMBL5440741 0.72 TDP1 (0.43) CYP3A4CYP2C19TDP1SMN1; SMN2KDM4E
SCHEMBL794180 0.68 MAOB (0.46) MAPK1MAOBSIGMAR1KCNH2
SCHEMBL8817971 0.68 MAOB (0.46) MAPK1MAOBTACR1SIGMAR1
SCHEMBL30688325 0.68 CYP1A2 (0.46) MAOBCYP3A4CYP1A2TDP1KDM4E
SCHEMBL3204506 0.67 CYP1A2 (0.72) CYP3A4CYP1A2CYP2D6CYP2C9CYP2C19
SCHEMBL9226100 0.67 MAOB (0.44) MAPK1MAOBCYP3A4CYP1A2CYP2D6
SCHEMBL11967590 0.65 MAOB (0.43) MAPK1MAOBLMNASIGMAR1KCNH2
SCHEMBL11498274 0.65 MAOB (0.43) MAPK1MAOBCYP3A4CYP2C19SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1294695-A2 SUBSTITUTED DIAMIDE DERIVATIVES USEFUL AS MOTILIN ANTAGONISTS Ortho-McNeil Pharmaceutical, Inc. (US) 2003-03-26 EP claimed
WO-2001085694-A2 SUBSTITUTED DIAMIDE DERIVATIVES USEFUL AS MOTILIN ANTAGONISTS ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) 2001-11-15 WO claimed