SCHEMBL6982137

SCHEMBL6982137

Cc1c(C)c2c(c(C)c1N)CC(C)(CN1CCNCC1)O2

nearest known ligand 0.32

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
USP2 O75604 1/20 0.32
TP53 P04637 1/20 0.32
CYP3A4 P08684 1/20 0.32
CYP2C9 P11712 1/20 0.32
ALOX15 P16050 1/20 0.32
TSHR P16473 1/20 0.32
NFKB1 P19838 1/20 0.32
THPO P40225 1/20 0.32
HIF1A Q16665 1/20 0.32
LCK P06239 1/20 0.32
FYN P06241 1/20 0.32
ADORA3 P0DMS8 1/20 0.32
DRD2 P14416 1/20 0.32
ADRA1D P25100 1/20 0.32
MAPK3 P27361 1/20 0.32
HTR2C P28335 1/20 0.32
MC4R P32245 1/20 0.32
HRH1 P35367 1/20 0.32
OPRM1 P35372 1/20 0.32
DRD3 P35462 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL6974806 0.99 GMNN (0.33) USP2TP53CYP3A4CYP2C9ALOX15
SCHEMBL8713753 0.86 USP2 (0.38) USP2TP53CYP3A4CYP2C9ALOX15
SCHEMBL6981092 0.80 DRD3 (0.34) USP2TP53CYP3A4CYP2C9ALOX15
SCHEMBL6985052 0.79 USP2 (0.32) USP2TP53CYP3A4CYP2C9ALOX15
SCHEMBL8573862 0.78 LMNA (0.42) TSHRLMNAKMT2ATDP1
SCHEMBL6985365 0.78 LMNA (0.42) TP53CYP3A4HIF1AMC4RLMNA
SCHEMBL6983488 0.78 DRD2 (0.41) USP2TP53CYP3A4CYP2C9ALOX15
Hydrochloric Acid SCHEMBL6979044 0.77 LMNA (0.41) TP53TSHRHIF1AMC4RLMNA
Hydrochloric Acid SCHEMBL6976169 0.77 LMNA (0.41) TSHRGMNNLMNAMAPTBLM
Hydrochloric Acid SCHEMBL6981668 0.77 SIGMAR1 (0.38) USP2TP53CYP3A4CYP2C9ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0901469-B1 ARYLALKYLPIPERAZINE COMPOUNDS AS ANTIOXIDANTS UNIV MONASH (AU) 2003-08-27 EP disclosed
EP-0923575-B1 CYCLIC ETHER COMPOUNDS AS SODIUM CHANNEL MODULATORS TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2003-03-12 EP disclosed
US-6232314-B1 SUCH AS 1-(2-(4-CHLOROPHENYL)-2-HYDROXY)ETHYL-4-(3,5-BIS(1,1-DIMETHYLETHYL)-4 -HYDROXYPHENYL)METHYLPIPERAZINE; USED TO TREAT STROKE, CARDIAC ARREST, ISCHAEMIA, HYPOXIA, HYPOGLYCAEMIA, EPILEPSY, AND AMYOTROPHIC LATERAL SCLEROSIS MONASH UNIVERSITY (AU) 2001-05-15 US disclosed
US-6172085-B1 CENTRAL NERVOUS SYSTEM AND PSYCHOLOGICAL DISORDERS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2001-01-09 US disclosed
EP-0901469-A4 ARYLALKYLPIPERAZINE COMPOUNDS AS ANTIOXIDANTS UNIV MONASH (AU) 2000-11-15 EP disclosed
EP-0923575-A1 CYCLIC ETHER COMPOUNDS AS SODIUM CHANNEL MODULATORS Takeda Chemical Industries, Ltd. (JP) 1999-06-23 EP disclosed
EP-0901469-A1 ARYLALKYLPIPERAZINE COMPOUNDS AS ANTIOXIDANTS MONASH UNIVERSITY (AU) 1999-03-17 EP disclosed
WO-1998008842-A1 CYCLIC ETHER COMPOUNDS AS SODIUM CHANNEL MODULATORS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1998-03-05 WO disclosed
WO-1997043259-A1 ARYLALKYLPIPERAZINE COMPOUNDS AS ANTIOXIDANTS MONASH UNIVERSITY (AU) 1997-11-20 WO disclosed