Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | GPR35 | Q9HC97 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TTR | P02766 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4727685 | 0.83 | PIM1 (0.44) | GPR35MAPTMEN1ALDH1A1KMT2A | |
| SCHEMBL26688244 | 0.83 | ALDH1A1 (0.44) | GPR35ALDH1A1HPGDALOX15ALOX12 | |
| SCHEMBL6983789 | 0.82 | LMNA (0.45) | CA1CA2GPR35KDM4EMAPT | |
| SCHEMBL2893781 | 0.80 | PIM1 (0.62) | MAPTMEN1ALDH1A1RECQLKMT2A | |
| SCHEMBL1609267 | 0.77 | GPR35 (0.51) | GPR35PIM1 | |
| SCHEMBL654558 | 0.73 | MAOA (0.67) | CA1CA2KDM4EMAPTTDP1 | |
| SCHEMBL30100149 | 0.73 | MAOA (0.67) | CA1CA2KDM4EMAPTTDP1 | |
| SCHEMBL2897463 | 0.72 | GPR35 (0.68) | GPR35MAPTTDP1ALDH1A1MAPK1 | |
| SCHEMBL1983840 | 0.71 | GPR35 (0.68) | GPR35PIM1 | |
| SCHEMBL28718422 | 0.70 | CA1 (0.79) | CA1CA2GPR35KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1011665-A4 | HETEROCYCLIC AGENTS | LILLY CO ELI (US) | 2001-09-12 | — | — | EP | claimed |
| EP-1011665-A1 | HETEROCYCLIC AGENTS | ELI LILLY AND COMPANY (US) | 2000-06-28 | — | — | EP | claimed |
| WO-1998040068-A1 | HETEROCYCLIC AGENTS | ELI LILLY AND COMPANY (US) | 1998-09-17 | — | — | WO | claimed |
| US-20030078251-A1 | Benzoxazepinones and their use as squalene synthase inhibitors | TAKEDA CHEMICAL INDUSTRIES LTD. (JP) | 2003-04-24 | — | — | US | disclosed |
| EP-1292585-A1 | BENZOXAZEPINONES AND THEIR USE AS SQUALENE SYNTHASE INHIBITORS | Takeda Chemical Industries, Ltd. (JP) | 2003-03-19 | — | — | EP | disclosed |
| WO-2001098282-A1 | BENZOXAZEPINONES AND THEIR USE AS SQUALENE SYNTHASE INHIBITORS | TAKEDA CHEMICAL INDUSTRIES, LTD (JP) | 2001-12-27 | — | — | WO | disclosed |
| EP-1011665-A4 | HETEROCYCLIC AGENTS | LILLY CO ELI (US) | 2001-09-12 | — | — | EP | disclosed |
| EP-1011665-A1 | HETEROCYCLIC AGENTS | ELI LILLY AND COMPANY (US) | 2000-06-28 | — | — | EP | disclosed |
| WO-1998040068-A1 | HETEROCYCLIC AGENTS | ELI LILLY AND COMPANY (US) | 1998-09-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030078251-A1 | Benzoxazepinones and their use as squalene synthase inhibitors | SQLE, CYP17A1, ACOX1 | CA1 3197/4885CA2 1246/4885GPR35 1942/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.