Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHMT2 | P34897 | 1/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.43 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.42 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5841553 | 0.99 | SHMT2 (0.54) | SHMT2SIGMAR1TLR9TLR7ACHE | |
| SCHEMBL5841208 | 0.88 | SHMT2 (0.44) | SHMT2SIGMAR1TLR9TLR7 | |
| SCHEMBL6986781 | 0.88 | SHMT2 (0.43) | SHMT2SIGMAR1TLR9TLR7 | |
| Hydrochloric Acid SCHEMBL5840340 | 0.88 | SHMT2 (0.43) | SHMT2SIGMAR1TLR9TLR7 | |
| Hydrochloric Acid SCHEMBL5842747 | 0.87 | SHMT2 (0.42) | SHMT2SIGMAR1TLR9TLR7 | |
| SCHEMBL6988480 | 0.86 | SIGMAR1 (0.45) | SHMT2SIGMAR1TLR9TLR7POLB | |
| Hydrochloric Acid SCHEMBL5840992 | 0.85 | SIGMAR1 (0.45) | SHMT2SIGMAR1TLR9TLR7POLB | |
| SCHEMBL6986873 | 0.85 | SHMT2 (0.44) | SHMT2SIGMAR1TLR9TLR7 | |
| Hydrochloric Acid SCHEMBL5840949 | 0.84 | SHMT2 (0.44) | SHMT2SIGMAR1TLR9TLR7 | |
| SCHEMBL6986827 | 0.83 | SIGMAR1 (0.47) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1275647-B1 | Octahydro-2H-pyrido[1,2-a]pyrazine derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-11-12 | — | — | EP | disclosed |
| EP-1275647-A1 | Octahydro-2H-pyrido[1,2-a]pyrazine derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2003-01-15 | — | — | EP | disclosed |