Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | CES2 | O00748 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | CCR3 | P51677 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6983251 | 0.84 | GAA (0.47) | ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL7815962 | 0.80 | OPRM1 (0.35) | ALDH1A1HSD11B1KMT2AMAPTL3MBTL1 | |
| SCHEMBL6967893 | 0.78 | CNR1 (0.40) | ALDH1A1HSD11B1CNR1PTGDR2KMT2A | |
| SCHEMBL11816794 | 0.76 | HSD11B1 (0.43) | ALDH1A1HSD11B1CNR1EPHX2KMT2A | |
| SCHEMBL6977901 | 0.75 | CNR1 (0.41) | ALDH1A1CNR1EPHX2KMT2AMAPT | |
| SCHEMBL6981407 | 0.74 | CNR1 (0.37) | ALDH1A1HSD11B1CNR1PTGDR2CES2 | |
| SCHEMBL377756 | 0.72 | MAPK1 (0.40) | ALDH1A1HSD11B1CNR1TSHRKMT2A | |
| SCHEMBL6970913 | 0.72 | OPRM1 (0.45) | ALDH1A1KMT2AMAPTL3MBTL1 | |
| SCHEMBL6980629 | 0.70 | APP (0.41) | ALDH1A1KMT2ACYP1A2CYP2C19MAPT | |
| SCHEMBL11806493 | 0.70 | AKR1B1 (0.40) | ALDH1A1HSD11B1CNR1TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1098893-B1 | CYCLIC COMPOUNDS USEFUL IN THE TREATMENT OF DYSLIPIDEMIA, ATHEROSCLEROSIS AND DIABETES, PHARMACEUTICAL COMPOSITIONS AND PREPARATION PROCESS | MERCK PATENT GMBH (DE) | 2003-03-26 | — | — | EP | disclosed |