Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1L1 | Q9UHC9 | 8/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PRKCA | P17252 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6984266 | 0.96 | NPC1L1 (0.41) | NPC1L1HTTCHRM2CHRM4CHRM1 | |
| SCHEMBL14677078 | 0.76 | GRIN2B (0.34) | — | |
| SCHEMBL7088438 | 0.75 | TRPA1 (0.32) | NPC1L1ALDH1A1 | |
| SCHEMBL7084911 | 0.74 | GFER (0.46) | CHRM2CHRM4CHRM1CHRM3ALDH1A1 | |
| SCHEMBL28702537 | 0.68 | RXFP1 (0.34) | HTTGAAALDH1A1MAPT | |
| SCHEMBL15937080 | 0.64 | GRIN2B (0.52) | NPC1L1HTT | |
| SCHEMBL5972238 | 0.62 | F10 (0.42) | CHRM2CHRM4CHRM1CHRM3ALDH1A1 | |
| SCHEMBL6982714 | 0.62 | F10 (0.41) | HTTCHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL6982717 | 0.62 | F10 (0.41) | HTTCHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL20407729 | 0.61 | LMNA (0.39) | NPC1L1HTTCHRM2CHRM4CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1294716-A1 | LACTAM INHIBITORS OF FACTOR XA AND METHOD | Bristol-Myers Squibb Company (US) | 2003-03-26 | — | — | EP | disclosed |
| WO-2001096331-A1 | LACTAM INHIBITORS OF FACTOR XA AND METHOD | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-12-20 | — | — | WO | disclosed |