Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 2/20 | 0.53 |
| ▸ | RXRB | P28702 | 2/20 | 0.53 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.52 |
| ▸ | PTPN5 | P54829 | 4/20 | 0.52 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | KIF11 | P52732 | 1/20 | 0.50 |
| ▸ | MGLL | Q99685 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | KMO | O15229 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL548430 | 0.87 | RXRA (0.53) | RXRARXRBPTPN1PTPN5CYP17A1 | |
| SCHEMBL9782559 | 0.85 | RXRA (0.42) | RXRARXRBPTPN1PTPN5CYP17A1 | |
| SCHEMBL11432364 | 0.84 | KMT2A (0.46) | CYP3A4CYP2C9HDAC4HDAC2HDAC8 | |
| SCHEMBL27544292 | 0.83 | KIF11 (0.50) | RXRARXRBPTPN1PTPN5CYP17A1 | |
| SCHEMBL18639619 | 0.82 | CYP2C9 (0.54) | RXRARXRBPTPN5CYP17A1CYP3A4 | |
| SCHEMBL779683 | 0.82 | KIF11 (0.70) | RXRARXRBPTPN1PTPN5CYP17A1 | |
| SCHEMBL3681495 | 0.82 | KIF11 (0.53) | RXRARXRBPTPN1PTPN5CYP17A1 | |
| SCHEMBL20194757 | 0.81 | RXRA (0.53) | RXRARXRBCYP3A4CNR2KMO | |
| SCHEMBL7855780 | 0.80 | RXRA (0.56) | RXRARXRBPTPN1PTPN5CYP17A1 | |
| SCHEMBL28423705 | 0.80 | CNR1 (0.53) | RXRARXRBPTPN1PTPN5CYP17A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1299379-A2 | LACTAM METALLOPROTEASE INHIBITORS | Bristol-Myers Squibb Pharma Company (US) | 2003-04-09 | — | — | EP | disclosed |
| WO-2002004416-A2 | LACTAM METALLOPROTEASE INHIBITORS | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2002-01-17 | — | — | WO | disclosed |
| EP-1054877-A1 | NOVEL CYCLIC SULFONAMIDE DERIVATIVES AS METALLOPROTEINASE INHIBITORS | Du Pont Pharmaceuticals Company (US) | 2000-11-29 | — | — | EP | disclosed |
| WO-1999041246-A1 | NOVEL CYCLIC SULFONAMIDE DERIVATIVES AS METALLOPROTEINASE INHIBITORS | DU PONT PHARMACEUTICALS COMPANY (US) | 1999-08-19 | — | — | WO | disclosed |