Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.74 |
| ▸ | TP53 | P04637 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 4/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 5/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10487884 | 0.87 | ALDH1A1 (0.55) | HPGDALDH1A1SMN1; SMN2KDM4ETP53 | |
| SCHEMBL6982894 | 0.85 | HPGD (1.00) | HPGDALDH1A1SMN1; SMN2KDM4ETP53 | |
| SCHEMBL30877025 | 0.85 | HPGD (1.00) | HPGDALDH1A1SMN1; SMN2KDM4ETP53 | |
| SCHEMBL10143728 | 0.83 | LMNA (0.74) | HPGDALDH1A1SMN1; SMN2KDM4ETP53 | |
| SCHEMBL17242694 | 0.83 | KDM4E (0.50) | HPGDALDH1A1SMN1; SMN2KDM4EMEN1 | |
| SCHEMBL19291210 | 0.82 | HPGD (0.80) | HPGDALDH1A1SMN1; SMN2KDM4ETP53 | |
| SCHEMBL17242542 | 0.80 | CA12 (0.53) | HPGDALDH1A1SMN1; SMN2KDM4EHDAC1 | |
| SCHEMBL7593290 | 0.78 | MEN1 (0.77) | HPGDALDH1A1SMN1; SMN2KDM4ETP53 | |
| SCHEMBL1067505 | 0.78 | HPGD (0.78) | HPGDALDH1A1SMN1; SMN2KDM4ETP53 | |
| SCHEMBL6256566 | 0.77 | KMT2A (0.79) | HPGDALDH1A1SMN1; SMN2KDM4ETP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4883800-A | DIABETES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-11-28 | — | — | US | disclosed |
| US-4734419-A | Quinazoline derivatives, compositions thereof and their use in treating diabetic complications | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-03-29 | — | — | US | disclosed |
| EP-0218999-A2 | New quinazoline derivatives, process for their production and pharmaceutical compositions comprising them | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1987-04-22 | — | — | EP | disclosed |