Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | GHSR | Q92847 | 3/20 | 0.38 |
| ▸ | JUN | P05412 | 2/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | SCD | O00767 | 5/20 | 0.38 |
| ▸ | F10 | P00742 | 2/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6987898 | 0.88 | MAPK14 (0.38) | KDM4EPOLBMAPK1SMN1; SMN2GHSR | |
| SCHEMBL6982128 | 0.82 | SCD (0.42) | SCD | |
| SCHEMBL6986945 | 0.82 | F10 (0.53) | KDM4EGHSRMAPK14F10SMYD3 | |
| Hydrochloric Acid SCHEMBL6985678 | 0.81 | SCD (0.42) | SCD | |
| Hydrochloric Acid SCHEMBL6985167 | 0.81 | F10 (0.53) | KDM4EGHSRMAPK14F10SMYD3 | |
| SCHEMBL6988687 | 0.79 | LMNA (0.45) | POLBGHSRMAPK14 | |
| SCHEMBL6986755 | 0.78 | MAPK14 (0.39) | KDM4EPOLBMAPK1SMN1; SMN2GHSR | |
| SCHEMBL6985540 | 0.77 | MAPK14 (0.40) | KDM4EGHSRMAPK14SCD | |
| SCHEMBL6984410 | 0.77 | MAPK14 (0.39) | KDM4EPOLBMAPK1SMN1; SMN2GHSR | |
| Hydrochloric Acid SCHEMBL6983385 | 0.75 | SIGLEC9 (0.40) | KDM4EPOLBMAPK1SMN1; SMN2SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1289950-A1 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2003-03-12 | — | — | EP | disclosed |
| WO-2001096296-A1 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2001-12-20 | — | — | WO | disclosed |