Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 2/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | GHSR | Q92847 | 5/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | DRD2 | P14416 | 3/20 | 0.34 |
| ▸ | DRD3 | P35462 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6984410 | 0.87 | MAPK14 (0.39) | MAPK14THRBFAAHGHSRKDM4E | |
| SCHEMBL6988687 | 0.86 | LMNA (0.45) | MAPK14THRBFAAHGHSRPOLB | |
| SCHEMBL6985540 | 0.86 | MAPK14 (0.40) | MAPK14FAAHGHSRKDM4EALDH1A1 | |
| SCHEMBL6987898 | 0.79 | MAPK14 (0.38) | MAPK14GHSRKDM4ESMN1; SMN2POLB | |
| SCHEMBL6986945 | 0.78 | F10 (0.53) | MAPK14GHSRKDM4EALDH1A1MAPT | |
| SCHEMBL6982897 | 0.78 | KDM4E (0.42) | MAPK14GHSRKDM4ESMN1; SMN2POLB | |
| Hydrochloric Acid SCHEMBL6985167 | 0.78 | F10 (0.53) | MAPK14GHSRKDM4EALDH1A1MAPT | |
| SCHEMBL6982128 | 0.75 | SCD (0.42) | MAPT | |
| Hydrochloric Acid SCHEMBL6985678 | 0.75 | SCD (0.42) | MAPT | |
| SCHEMBL4837049 | 0.74 | MAPK14 (0.42) | MAPK14THRBFAAHGHSRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1289972-A1 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2003-03-12 | — | — | EP | disclosed |
| WO-2001096323-A1 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2001-12-20 | — | — | WO | disclosed |