Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 12/20 | 0.45 |
| ▸ | HTR1B | P28222 | 10/20 | 0.45 |
| ▸ | HTR1D | P28221 | 9/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | THRA | P10827 | 4/20 | 0.43 |
| ▸ | THRB | P10828 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6987620 | 0.93 | THRA (0.45) | HTR1AHTR1BHTR1DCYP2D6HTR2A | |
| SCHEMBL6985253 | 0.89 | HTR1A (0.45) | HTR1AHTR1BHTR1DMAPTMAPK1 | |
| SCHEMBL6985820 | 0.86 | THRA (0.46) | HTR1AHTR1BHTR1DMAPTMAPK1 | |
| SCHEMBL6514328 | 0.86 | THRB (0.60) | HTR1AHTR1BHTR1DMAPTMAPK1 | |
| SCHEMBL6515156 | 0.85 | THRB (0.59) | HTR1AHTR1BHTR1DMAPTMAPK1 | |
| SCHEMBL6516483 | 0.85 | THRA (0.48) | HTR1AHTR1BHTR1DMAPTMAPK1 | |
| SCHEMBL6521742 | 0.84 | THRA (0.47) | HTR1AHTR1BHTR1DMAPTMAPK1 | |
| SCHEMBL7087277 | 0.83 | HTR1B (0.52) | HTR1AHTR1BHTR1DMAPTMAPK1 | |
| SCHEMBL6513911 | 0.83 | THRB (0.61) | HTR1AHTR1BHTR1DKDM4EMEN1 | |
| SCHEMBL7089914 | 0.82 | THRA (0.47) | HTR1AHTR1BHTR1DCYP2D6HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1347959-A1 | INDOLE DERIVATIVES AS LIGANDS OF THYROID RECEPTORS | Bayer Aktiengesellschaft (DE) | 2003-10-01 | — | — | EP | disclosed |
| WO-2002051805-A1 | INDOLE DERIVATIVES AS LIGANDS OF THYROID RECEPTORS | BAYER AKTIENGESELLSCHAFT (DE) | 2002-07-04 | — | — | WO | disclosed |