Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 7/20 | 0.47 |
| ▸ | THRB | P10828 | 7/20 | 0.47 |
| ▸ | HTR1A | P08908 | 4/20 | 0.43 |
| ▸ | HTR1B | P28222 | 4/20 | 0.43 |
| ▸ | HTR1D | P28221 | 4/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6985820 | 0.94 | THRA (0.46) | THRATHRBHTR1AHTR1BHTR1D | |
| SCHEMBL6987620 | 0.89 | THRA (0.45) | THRATHRBHTR1AHTR1BHTR1D | |
| SCHEMBL7089913 | 0.88 | THRA (0.47) | THRATHRBHTR1AHTR1BHTR1D | |
| SCHEMBL7085216 | 0.86 | THRA (0.44) | THRATHRBHTR1AHTR1BCYP2D6 | |
| SCHEMBL6523656 | 0.84 | THRA (0.64) | THRATHRBHTR1AHTR1BHTR1D | |
| SCHEMBL6985214 | 0.84 | CYP2D6 (0.45) | THRATHRBHTR1AHTR1BHTR1D | |
| SCHEMBL6516186 | 0.84 | THRA (0.51) | THRATHRBHTR1AHTR1BHTR1D | |
| SCHEMBL7085754 | 0.83 | THRA (0.48) | THRATHRBHTR1AHTR1BHTR1D | |
| SCHEMBL6983004 | 0.82 | HTR1A (0.45) | THRATHRBHTR1AHTR1BHTR1D | |
| SCHEMBL6985253 | 0.82 | HTR1A (0.45) | THRATHRBHTR1AHTR1BHTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1347959-A1 | INDOLE DERIVATIVES AS LIGANDS OF THYROID RECEPTORS | Bayer Aktiengesellschaft (DE) | 2003-10-01 | — | — | EP | disclosed |
| WO-2002051805-A1 | INDOLE DERIVATIVES AS LIGANDS OF THYROID RECEPTORS | BAYER AKTIENGESELLSCHAFT (DE) | 2002-07-04 | — | — | WO | disclosed |