Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | CASP6 | P55212 | 1/20 | 0.56 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.48 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.42 |
| ▸ | HTR2A | P28223 | 4/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15324144 | 0.82 | MTNR1A (0.52) | GAAALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL6770793 | 0.81 | KDM4E (0.64) | GAAALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL26307482 | 0.80 | HTR2A (0.55) | ALDH1A1KDM4EMEN1KMT2AADRB2 | |
| SCHEMBL25074718 | 0.78 | HTR6 (0.68) | HTR2AHTR1AHTR2CHTR2BHTR6 | |
| SCHEMBL30928245 | 0.78 | HTR6 (0.68) | HTR2AHTR1AHTR2CHTR2BHTR6 | |
| SCHEMBL24723796 | 0.77 | HTR2A (0.38) | ALDH1A1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL24043692 | 0.74 | KMT2A (0.58) | GAAALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL7360256 | 0.74 | HTR2A (0.62) | GAAALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL3562093 | 0.74 | ALDH1A1 (0.69) | GAAALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL6287959 | 0.74 | ALDH1A1 (0.69) | GAAALDH1A1KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0839806-B1 | Substituted tricyclics | LILLY CO ELI (US) | 2003-07-09 | — | — | EP | disclosed |
| WO-1998018464-A1 | SUBSTITUTED TRICYCLICS | ELI LILLY AND COMPANY (US) | 1998-05-07 | — | — | WO | disclosed |
| EP-0839806-A1 | Substituted tricyclics | ELI LILLY AND COMPANY (US) | 1998-05-06 | — | — | EP | disclosed |