Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 14/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.52 |
| ▸ | DRD2 | P14416 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6984019 | 0.91 | HTR1A (0.59) | HTR1AADRA1ADRD2 | |
| SCHEMBL5654896 | 0.85 | ALDH1A1 (0.57) | HTR1APOLBHPGD | |
| SCHEMBL14525211 | 0.82 | PLA2G7 (0.45) | HTR1AKMT2A | |
| SCHEMBL6985229 | 0.81 | NPC1 (0.55) | POLB | |
| SCHEMBL6981118 | 0.80 | HPGD (0.61) | HTR1AADRA1ADRD2KMT2APOLB | |
| SCHEMBL3909631 | 0.78 | HPGD (0.60) | HTR1AADRA1ADRD2KMT2APOLB | |
| Methane SCHEMBL7454180 | 0.74 | HPGD (0.65) | HTR1AADRA1ADRD2KMT2APOLB | |
| SCHEMBL2109099 | 0.74 | TP53 (0.49) | KMT2APOLBHPGD | |
| SCHEMBL27972639 | 0.73 | CA12 (0.43) | KMT2AHPGD | |
| SCHEMBL3845345 | 0.73 | AVPR1A (0.57) | KMT2APOLBHPGDPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946546-B1 | PYRIDIN-2-YL-METHYLAMINE DERIVATIVES, METHOD OF PREPARING AND APPLICATION AS MEDICINE | PF MEDICAMENT (FR) | 2003-06-25 | — | — | EP | disclosed |
| US-6020345-A | Pyridin-2-yl-methylamine derivatives, method of preparing and application as medicine | PIERRE FABRE MEDICAMENT (FR) | 2000-02-01 | — | — | US | disclosed |
| EP-0946546-A1 | PYRIDIN-2-YL-METHYLAMINE DERIVATIVES, METHOD OF PREPARING AND APPLICATION AS MEDICINE | PIERRE FABRE MEDICAMENT (FR) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998022459-A1 | PYRIDIN-2-YL-METHYLAMINE DERIVATIVES, METHOD OF PREPARING AND APPLICATION AS MEDICINE | PIERRE FABRE MEDICAMENT (FR) | 1998-05-28 | — | — | WO | disclosed |