Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 7/20 | 0.48 |
| ▸ | NOS2 | P35228 | 3/20 | 0.39 |
| ▸ | NSD2 | O96028 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | SALL4 | Q9UJQ4 | 2/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6986629 | 1.00 | NOS3 (0.48) | NOS3NOS2NSD2OPRM1OPRD1 | |
| SCHEMBL6983548 | 0.85 | NOS3 (0.51) | NOS3NOS2CYP1A2 | |
| SCHEMBL6986785 | 0.82 | NOS3 (0.46) | NOS3NOS2NSD2OPRM1OPRD1 | |
| SCHEMBL6986673 | 0.82 | NOS3 (0.45) | NOS3NOS2CYP19A1KDM4EALDH1A1 | |
| SCHEMBL6986359 | 0.81 | NOS3 (0.44) | NOS3NOS2NSD2CYP19A1KDM4E | |
| SCHEMBL6986291 | 0.81 | NOS3 (0.44) | NOS3NOS2CYP19A1 | |
| SCHEMBL6988233 | 0.81 | NOS3 (0.44) | NOS3NOS2CYP19A1 | |
| SCHEMBL13651003 | 0.81 | NSD2 (0.36) | NSD2OPRM1OPRD1HKDC1HSD17B10 | |
| SCHEMBL4115164 | 0.76 | NOS3 (0.42) | NOS3NOS2 | |
| SCHEMBL6985896 | 0.72 | MAOA (0.44) | NOS3NOS2NSD2OPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8183378-B2 | Ligands, their preparation and uses thereof in asymmetric reactions | Li, Chao-Jun (CA) | 2012-05-22 | — | — | US | disclosed |
| US-8183378-B2 | Ligands, their preparation and uses thereof in asymmetric reactions | Li, Chao-Jun (CA) | 2012-05-22 | — | — | US | disclosed |
| US-20090247757-A1 | LIGANDS, THEIR PREPARATION AND USES THEREOF IN ASYMMETRIC REACTIONS | CHAO-JUN LI (CA) | 2009-10-01 | — | — | US | disclosed |
| US-20090247757-A1 | LIGANDS, THEIR PREPARATION AND USES THEREOF IN ASYMMETRIC REACTIONS | CHAO-JUN LI (CA) | 2009-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090247757-A1 | LIGANDS, THEIR PREPARATION AND USES THEREOF IN ASYMMETRIC REACTIONS | OGFR, OR10J3, OPRL1 | NOS3 1412/4885NOS2 2955/4885NSD2 3711/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.