Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 7/20 | 0.45 |
| ▸ | NOS2 | P35228 | 3/20 | 0.36 |
| ▸ | HTR7 | P34969 | 4/20 | 0.32 |
| ▸ | HTR1A | P08908 | 3/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6983548 | 0.82 | NOS3 (0.51) | NOS3NOS2HTR7HTR1A | |
| SCHEMBL6983396 | 0.82 | NOS3 (0.48) | NOS3NOS2CYP19A1KDM4EALDH1A1 | |
| SCHEMBL6986629 | 0.82 | NOS3 (0.48) | NOS3NOS2CYP19A1KDM4EALDH1A1 | |
| SCHEMBL6986359 | 0.78 | NOS3 (0.44) | NOS3NOS2CYP19A1KDM4EMAPK1 | |
| SCHEMBL6986291 | 0.78 | NOS3 (0.44) | NOS3NOS2CYP19A1 | |
| SCHEMBL6988233 | 0.78 | NOS3 (0.44) | NOS3NOS2CYP19A1 | |
| SCHEMBL6991272 | 0.74 | MAOA (0.42) | NOS3NOS2HTR7HTR1AKDM4E | |
| SCHEMBL4115164 | 0.73 | NOS3 (0.42) | NOS3NOS2 | |
| SCHEMBL7069207 | 0.68 | DNMT1 (0.42) | KDM4EALDH1A1 | |
| SCHEMBL6986785 | 0.64 | NOS3 (0.46) | NOS3NOS2KDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8183378-B2 | Ligands, their preparation and uses thereof in asymmetric reactions | Li, Chao-Jun (CA) | 2012-05-22 | — | — | US | disclosed |
| US-8183378-B2 | Ligands, their preparation and uses thereof in asymmetric reactions | Li, Chao-Jun (CA) | 2012-05-22 | — | — | US | disclosed |
| US-20090247757-A1 | LIGANDS, THEIR PREPARATION AND USES THEREOF IN ASYMMETRIC REACTIONS | CHAO-JUN LI (CA) | 2009-10-01 | — | — | US | disclosed |
| US-20090247757-A1 | LIGANDS, THEIR PREPARATION AND USES THEREOF IN ASYMMETRIC REACTIONS | CHAO-JUN LI (CA) | 2009-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090247757-A1 | LIGANDS, THEIR PREPARATION AND USES THEREOF IN ASYMMETRIC REACTIONS | OGFR, OR10J3, OPRL1 | NOS3 1412/4885NOS2 2955/4885HTR7 139/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.