SCHEMBL6983539

SCHEMBL6983539

COc1ccc(N2CCC(c3nc(N)nc(N)n3)CC2)cc1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DHFR P00374 1/20 0.51
ALDH1A1 P00352 4/20 0.49
GAA P10253 2/20 0.49
HTR3E A5X5Y0 1/20 0.46
HTR3B O95264 1/20 0.46
ADRB1 P08588 1/20 0.46
HTR3A P46098 1/20 0.46
HTR3D Q70Z44 1/20 0.46
HTR3C Q8WXA8 1/20 0.46
SIGMAR1 Q99720 1/20 0.46
MAPT P10636 5/20 0.46
RAB9A P51151 3/20 0.46
KMT2A Q03164 1/20 0.46
HRH4 Q9H3N8 1/20 0.44
HRH3 Q9Y5N1 1/20 0.44
SLC18A3 Q16572 1/20 0.44
SMN1; SMN2 Q16637 2/20 0.43
LMNA P02545 2/20 0.43
CYP1A2 P05177 1/20 0.43
CYP3A4 P08684 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6982632 0.80 DHFR (0.48) DHFRGAAMAPTLMNAL3MBTL1
SCHEMBL10691060 0.79 DHFR (0.51) DHFRALDH1A1GAAHTR3EHTR3B
SCHEMBL6978036 0.78 DHFR (0.50) DHFRMAPTHRH3DRD2
SCHEMBL10691450 0.78 DHFR (0.65) DHFRALDH1A1GAAMAPTRAB9A
SCHEMBL10807304 0.76 DHFR (0.56) DHFRALDH1A1GAAHTR3EHTR3B
SCHEMBL7324178 0.75 HTR3E (0.58) DHFRALDH1A1GAAHTR3EHTR3B
Hydrochloric Acid SCHEMBL17557714 0.73 HTR3E (0.56) DHFRALDH1A1GAAHTR3EHTR3B
SCHEMBL13035732 0.73 POLB (0.60) GAAHTR3EHTR3BADRB1HTR3A
SCHEMBL3287391 0.72 ACHE (0.51) SIGMAR1MAPTKMT2AHRH4HRH3
SCHEMBL10686950 0.72 GAA (0.47) DHFRALDH1A1GAAHTR3EHTR3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1037886-B1 TRIAZINE ANGIOGENESIS INHIBITORS ABBOTT LAB (US) 2003-05-02 EP claimed
US-6288228-B1 DIAMINOTRIAZINE DERIVATIVES ABBOTT LABORATORIES 2001-09-11 US claimed
US-6150362-A ADMINISTERING 1,3,5-SUBSTITUTED TRIAZINE COMPOUNDS TO THE PATIENT SUFFERING FROM ANGIOGENIC DISEASES ABBVIE INC. 2000-11-21 US claimed
EP-1037886-A1 TRIAZINE ANGIOGENESIS INHIBITORS Abbott Laboratories (US) 2000-09-27 EP claimed
WO-1999031088-A1 TRIAZINE ANGIOGENESIS INHIBITORS ABBOTT LABORATORIES (US) 1999-06-24 WO claimed
EP-1037886-B1 TRIAZINE ANGIOGENESIS INHIBITORS ABBOTT LAB (US) 2003-05-02 EP disclosed
US-6288228-B1 DIAMINOTRIAZINE DERIVATIVES ABBOTT LABORATORIES 2001-09-11 US disclosed
US-6150362-A ADMINISTERING 1,3,5-SUBSTITUTED TRIAZINE COMPOUNDS TO THE PATIENT SUFFERING FROM ANGIOGENIC DISEASES ABBVIE INC. 2000-11-21 US disclosed
EP-1037886-A1 TRIAZINE ANGIOGENESIS INHIBITORS Abbott Laboratories (US) 2000-09-27 EP disclosed
WO-1999031088-A1 TRIAZINE ANGIOGENESIS INHIBITORS ABBOTT LABORATORIES (US) 1999-06-24 WO disclosed