Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6232035 | 0.86 | ALDH1A1 (0.43) | ALDH1A1MAPTLMNATSHRPOLB | |
| SCHEMBL17242666 | 0.84 | TSHR (0.45) | ALDH1A1MAPTLMNATSHRPOLB | |
| SCHEMBL2718367 | 0.80 | MAPT (0.44) | ALDH1A1MAPTLMNATSHRPOLB | |
| SCHEMBL2337048 | 0.77 | POLB (0.47) | ALDH1A1MAPTLMNATSHRPOLB | |
| SCHEMBL31098941 | 0.74 | KCNH2 (0.39) | ALDH1A1MAPTLMNATSHRPOLB | |
| SCHEMBL5484250 | 0.74 | TSHR (0.44) | ALDH1A1MAPTLMNATSHRPOLB | |
| SCHEMBL17186886 | 0.74 | ALDH1A1 (0.42) | ALDH1A1MAPTLMNATSHRPOLB | |
| SCHEMBL17186888 | 0.74 | ALDH1A1 (0.41) | ALDH1A1MAPTLMNATSHRPOLB | |
| SCHEMBL25221130 | 0.72 | MAPT (0.36) | ALDH1A1MAPTLMNATSHRPOLB | |
| SCHEMBL588286 | 0.71 | TSHR (0.55) | ALDH1A1MAPTLMNATSHRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1220844-B1 | ARYL SULFONAMIDE-SUBSTITUTED BENZIMIDAZOL DERIVATIVES THEREOF AS TRYPTASE INHIBITORS | BOEHRINGER INGELHEIM PHARMA (DE) | 2003-04-09 | — | — | EP | disclosed |
| EP-1220844-A1 | ARYL SULFONAMIDE-SUBSTITUTED BENZIMIDAZOL DERIVATIVES THEREOF AS TRYPTASE INHIBITORS | Boehringer Ingelheim Pharma KG (DE) | 2002-07-10 | — | — | EP | disclosed |
| US-6365584-B1 | FOR PROPHYLAXIS AND THERAPY OF INFLAMMATORY AND/OR ALLERGIC DISEASES, LUNG FIBROSIS, FIBROSING ALVEOLITIS AND SCARRING, COLLAGENOSES SUCH AS LUPUS ERYTHEMATODES AND SCLERODERMIA AS WELL AS ARTERIOSCLEROSIS, PSORIASIS AND NEOPLASM | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-04-02 | — | — | US | disclosed |
| WO-2001023360-A1 | ARYL SULFONAMIDE-SUBSTITUTED BENZIMIDAZOL DERIVATIVES THEREOF AS TRYPTASE INHIBITORS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-04-05 | — | — | WO | disclosed |