Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | QPCT | Q16769 | 1/20 | 0.38 |
| ▸ | CAMK2D | Q13557 | 10/20 | 0.37 |
| ▸ | PDE4A | P27815 | 2/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6980999 | 0.93 | GSK3B (0.42) | GSK3BQPCTCAMK2DPDE4APDE4B | |
| Trifluoroacetic Acid SCHEMBL6983727 | 0.82 | CAMK2D (0.44) | CAMK2DMAPTCCNT1CCNA2CDK2 | |
| Trifluoroacetic Acid SCHEMBL6980387 | 0.82 | CAMK2D (0.39) | CAMK2DCCNT1CCNA2CDK2CDK9 | |
| Trifluoroacetic Acid SCHEMBL6978549 | 0.82 | GSK3B (0.39) | GSK3BQPCTCAMK2DCCNT1CCNA2 | |
| Trifluoroacetic Acid SCHEMBL6982808 | 0.81 | CAMK2D (0.46) | GSK3BCAMK2DMAPTCCNT1CCNA2 | |
| Trifluoroacetic Acid SCHEMBL6985258 | 0.80 | CAMK2D (0.39) | CAMK2DCCNT1CCNA2CDK2CDK9 | |
| Trifluoroacetic Acid SCHEMBL6984540 | 0.79 | CAMK2D (0.46) | GSK3BCAMK2DMAPTCCNT1CCNA2 | |
| Trifluoroacetic Acid SCHEMBL6977475 | 0.78 | CAMK2D (0.48) | CAMK2DCCNT1CCNA2CDK2CDK9 | |
| Trifluoroacetic Acid SCHEMBL6985276 | 0.77 | CAMK2D (0.49) | GSK3BCAMK2DMAPTCCNT1CDK2 | |
| Trifluoroacetic Acid SCHEMBL6981733 | 0.76 | CAMK2D (0.42) | GSK3BCAMK2DMAPTCCNT1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1095039-B1 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRAZENECA AB (SE) | 2003-08-27 | — | — | EP | disclosed |
| US-6346625-B1 | ENZYME INHIBITORS FOR PROTEIN KINASES | ASTRAZENECA AB (SE) | 2002-02-12 | — | — | US | disclosed |