Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMK2D | Q13557 | 10/20 | 0.46 |
| ▸ | PRKACA | P17612 | 5/20 | 0.46 |
| ▸ | PRKACG | P22612 | 5/20 | 0.46 |
| ▸ | PRKACB | P22694 | 5/20 | 0.46 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.45 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.42 |
| ▸ | CDK9 | P50750 | 2/20 | 0.42 |
| ▸ | CDK4 | P11802 | 3/20 | 0.40 |
| ▸ | CCND1 | P24385 | 3/20 | 0.40 |
| ▸ | LDHA | P00338 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 2/20 | 0.37 |
| ▸ | CDK2 | P24941 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.37 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.37 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | PRKCG | P05129 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | PRKCB | P05771 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL6985276 | 0.98 | CAMK2D (0.49) | CAMK2DPRKACAPRKACGPRKACBRPS6KB1 | |
| Trifluoroacetic Acid SCHEMBL6986094 | 0.95 | PRKACA (0.45) | CAMK2DPRKACAPRKACGPRKACBRPS6KB1 | |
| SCHEMBL6979319 | 0.93 | CAMK2D (0.52) | CAMK2DPRKACAPRKACGPRKACBRPS6KB1 | |
| Trifluoroacetic Acid SCHEMBL6982571 | 0.91 | CCNT1 (0.44) | CAMK2DPRKACAPRKACGPRKACBRPS6KB1 | |
| SCHEMBL6981937 | 0.90 | CAMK2D (0.56) | CAMK2DPRKACAPRKACGPRKACBRPS6KB1 | |
| Trifluoroacetic Acid SCHEMBL6984632 | 0.88 | PRKCB (0.46) | CAMK2DPRKACAPRKACGPRKACBRPS6KB1 | |
| SCHEMBL6980064 | 0.87 | PRKACA (0.52) | CAMK2DPRKACAPRKACGPRKACBRPS6KB1 | |
| Trifluoroacetic Acid SCHEMBL6982808 | 0.87 | CAMK2D (0.46) | CAMK2DRPS6KB1CCNT1CDK9PIM1 | |
| Trifluoroacetic Acid SCHEMBL6985258 | 0.86 | CAMK2D (0.39) | CAMK2DRPS6KB1CCNT1CDK9PIM1 | |
| Trifluoroacetic Acid SCHEMBL6984982 | 0.86 | TPSAB1 (0.40) | CAMK2DPRKACAPRKACGPRKACBRPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1095039-B1 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRAZENECA AB (SE) | 2003-08-27 | — | — | EP | disclosed |
| US-6346625-B1 | ENZYME INHIBITORS FOR PROTEIN KINASES | ASTRAZENECA AB (SE) | 2002-02-12 | — | — | US | disclosed |